Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease

Inclusion Criteria:

• Able to understand and sign an informed consent and HIPAA privacy document

• Greater than 18 years of age at time of informed consent

• Able and willing to follow protocol instructions

• Capable of performing at-home eye wash

• Must be willing to drop off samples and comply with study visit procedures

• For contact lens wearers, must wear lenses at least four hours per day, four days perweek

Exclusion Criteria:

• Current cigarette smokers

• Current participation in any investigational drug or device study. If subjects chooseto participate in another investigational drug or device study, they will bediscontinued from this study protocol.

• Current pregnancy or nursing as indicated by self-report. While not a safety issue,pregnancy or nursing influences the biochemical composition of the tear film.

• Any systemic health conditions that alter tear film physiology

• A history of ocular surgery within the past 12 months

• Any active ocular infection or inflammation

• Any present use of Accutane or ocular medications

• Any history of significant adverse reaction to lifitegrast or other components of thedrug product, or contraindication to the use of lifitegrast or other components of thedrug product

• Any prior exposure to lifitegrast.

• For normal and dry eye subjects, any history of contact lens wear within the pastthree months.

• For contact lens wearers, any change of soft contact lens brand or care solutionswithin 30 days prior to screening or any anticipation of changing current type/brandof contact lenses or care solutions throughout the 84 day study

• Any condition, which in the examiner's opinion, may put the subject at significantrisk, confound study results, or interfere with their participation in the study.