Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon

Last updated: January 16, 2018
Sponsor: Ain Shams University
Overall Status: Completed

Phase

4

Condition

Traumatic Brain Injury

Memory Loss

Neurologic Disorders

Treatment

N/A

Clinical Study ID

NCT03401515
1345 AUS
  • Ages 18-60
  • All Genders

Study Summary

Traumatic Brain Injury (TBI) is one of the leading causes of death. Severe TBT is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming. It is also autonomic dysfunction syndrome. This phenomenon is also associated with brain tumors, severe hydrocephalus and subarachnoid hemorrhage. Patients are presented by tachycardia, tachypnea hypertension, diaphoresis, dystonia, hyperthermia, and dilated pupils with elevated levels of plasma catecholamine and blood glucose .

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Patients with isolated blunt TBI

  • From 18 to 60 years old both sex

  • Not in need of mechanical ventilation

  • GCS on admission between 9 and 12

  • Rotterdam CT score from 2-4.

  • Normal Procalcitonin test to exclude infection.

Exclusion

Exclusion criteria:

  • Preexisting heart disease

  • Myocardial injury

  • Craniotomy

  • Preexisting cerebral dysfunction

  • Spinal cord injury

  • Diabetes mellitus

  • Severe liver or kidney disease

  • Patients with sepsis

Study Design

Total Participants: 60
Study Start date:
October 01, 2016
Estimated Completion Date:
August 01, 2017

Study Description

The sympathetic storming events can be triggered by suctioning, repositioning, or environmental stimuli. To differentiate sympathetic storming from similar conditions, symptoms and signs have to occur in TBI patients a minimum of 1 cycle per day for 3 consecutive days (body temperature of 38.5 °C or more, heart rate at least 120 beat / min, systolic blood pressure > 140 mmHg, respiratory rate > 20 breaths / min, in presence of dystonia, diaphoresis, agitation and laboratory investigations confirm elevated serum catecholamines. Beta blockers has a cardio protective effect via lowering heart rate, stroke volume and mean arterial blood pressure which limits myocardial O2 consumptions and guards against myocardial infarction. They also have neuron protective effects via reducing cerebral blood flow thus lowering O2 and glucose consumption as cerebral metabolism is reduced. Propranolol a nonselective B receptor antagonists works on β1 receptors in brain, heart, and kidney and β 2 receptors in lungs, liver, skeletal muscles, eye and arterioles.We suppose that using Beta - adrenergic receptor blockers as propranolol blunts the sympathetic storming phenomenon as it is a nonselective β inhibitor and has a lipophilic property which enables it to penetrate blood brain barrier.