Houston Emergency Opioid Engagement System

Last updated: December 5, 2024
Sponsor: The University of Texas Health Science Center, Houston
Overall Status: Active - Enrolling

Phase

4

Condition

Opioid Use Disorder

Treatment

Suboxone

Follow-up coaching

Referral to outpatient treatment

Clinical Study ID

NCT03396276
HSC-SBMI-17-1021
  • Ages > 18
  • All Genders

Study Summary

The Houston Emergency Response Opioid Engagement System (HEROES) is a community-based research program integrating assertive outreach, medication-assisted treatment, behavioral counseling, peer recovery support, and paramedic follow-up in Houston Texas. The objective is to compare differences in engagement and retention in treatment for individuals with opioid use disorder.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • In otherwise good health based on physician assessment and medical history

  • Tests positive in urine sample for opioids

  • Patients express a willingness to stop opioid use

  • Meet Diagnostic and Statistical Manual of Mental Disorders - Text Revision (DSM-IV-TR) criteria for opioid dependence

  • Patients must be able to speak English

  • Be agreeable to and capable of signing informed consent

Exclusion

Exclusion Criteria:

  • Non-English-speaking patients

  • Have a known sensitivity to buprenorphine or naloxone

  • Be physiologically dependent on alcohol, benzodiazepines or other drugs of abusethat require immediate medical attention. Other substance use diagnoses are notexclusionary.

  • Have a medical condition that would, in the opinion of the study physician, makeparticipation medically hazardous, including unstable cardiovascular disease,neurological deficits, trauma, acute hepatitis, stroke, and liver or renal disease)

  • Be acutely psychotic, severely depressed, and in need of inpatient treatment, or isan immediate suicide risk

  • Be a nursing or pregnant female

Study Design

Total Participants: 1500
Treatment Group(s): 4
Primary Treatment: Suboxone
Phase: 4
Study Start date:
April 01, 2018
Estimated Completion Date:
August 31, 2025

Study Description

The Houston Emergency Response Opioid Engagement System (HEROES) is a non-randomized cohort study based at the University of Texas Health Science Center of Houston. This study seeks to develop an emergency- initiated opioid system of care for individuals with prior opioid overdose and opioid use disorder. The study involves both assertive outreach on individuals who have recent overdoses within the last 72 hours, as well as individuals who are admitted to local hospital emergency departments. The study explores the effect of the combination of assertive outreach, same-day induction into medication-assisted treatment, ongoing maintenance treatment, behavioral counseling, peer recovery support, and paramedic follow-up on patient outcomes. The primary outcome is engagement and retention outpatient treatment. Secondary outcomes include quality of life assessment as well as subsequent relapses and overdoses. The hypothesis is that patients with earlier induction into MAT treatment in the emergency department, who receive routine follow-up, are more likely to engage and be retained in a longer-term treatment program for their addiction.

Connect with a study center

  • The University of Texas Health Science Center at Houston

    Houston, Texas 77030
    United States

    Site Not Available

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