Chidamide Combined With R-GDP in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Inclusion Criteria:

1. Ages: 18-75 years old

2. Relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL) previous treated withstandard chemoimmunotherapy

3. Not willing or not suitable for hematopoietic stem cell transplantation (HSCT)

4. Eastern Cooperative Oncology Group (ECOG) performance status (PS) index < 2

5. Informed consent available

6. Life expectancy of more than 3 months;

7. Ultrasonic cardiogram showed left ventricle ejection fraction ≥ 50%, EKG showed onsigns of myocardial ischemia, with no previous arrhythmia which need pharmacologicalintervention.

8. Bone marrow function: ANC ≥ 1.5 × 109/L, PLT ≥ 100 × 109/L, Hb ≥ 80g/L;

9. Liver function: total bilirubin, ALT and AST were <1.5 × UNL (the upper limit ofnormal value)

10. Renal function: Cr<1.5 × UNL and creatinine clearance > 50ml/min

Exclusion Criteria:

1. Prior history of treatment of HDAC inhibitor.

2. Plan of HSCT in the future

3. Significant pericardial effusion showed by chest CT scan

4. Prior history of other cancers except treated cervical or basal cell skin carcinoma,organ transplantation

5. Syphilis or human immunodeficiency virus (HIV) infection

6. Pregnant or lactating women

7. History of organ transplantation

8. Serious active infections (including hepatitis)

9. Serious neurological or psychiatric history, including dementia or epilepsy. Termination criteria:

10. Withdrew consent

11. Researchers think it is necessary to terminate the study;

12. Disease progression or death;

13. Poor compliance

14. Subclinical or clinical cardiac toxicity;

15. Unable to continue treatment because of severe toxicity