Utilization of Negative Pressure Suction to Reduce Aspiration in Oropharyngeal Dysphagia

Last updated: March 27, 2025
Sponsor: University of California, Davis
Overall Status: Active - Recruiting

Phase

N/A

Condition

Achalasia

Treatment

Negative Pressure Suction Catheter

Clinical Study ID

NCT03368079
836211
  • Ages > 18
  • All Genders

Study Summary

This is an investigator initiated prospective study to determine whether the use of a negative pressure suction in the hypopharynx will reduce the amount of aspiration during Video Fluoroscopic Swallowing Exam (VFSE) among patients with oropharyngeal dysphagia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with videofluoroscopic evidence of aspiration with Rosenbek PenetrationAspiration Scale (PAS) greater than 5 for all tested food consistencies

  • Gastrostomy tube dependence

  • Exhaustion of conventional treatment options (physical, medical, and surgicaltherapies)

Exclusion

Exclusion Criteria:

  • Complete PES stricture

  • Inability to follow commands

  • Current malignant disease

  • No gastrostomy tube present

  • Less than two years of cancer-free survival (if applicable)

  • Vulnerable populations: adults unable to consent, pregnant women, and prisoners

Study Design

Total Participants: 10
Treatment Group(s): 1
Primary Treatment: Negative Pressure Suction Catheter
Phase:
Study Start date:
January 30, 2016
Estimated Completion Date:
December 30, 2025

Study Description

During a properly coordinated swallow, the oropharynx, larynx, and hypopharynx undergo a series of movements that serve to prepare and expand the pharyngoesophageal segment (PES), which is the inlet into the esophagus. Under normal circumstances, a food bolus is safely propelled from the oropharynx, through the PES, and into the esophagus. Surgical and radiation therapy in the head and neck, as well as deficiencies such as poor coordination, mistiming, or obstructing lesions may prevent the food bolus from safely entering the esophagus and instead diverting toward the trachea.

A number of patients with severe oropharyngeal dysphagia are not able to tolerate any diet without risking aspiration and subsequent pneumonia, often to a degree severe enough that they cannot manage to safely swallow their secreted saliva. These patients depend on a gastrostomy feeding tube in order to obtain adequate daily nutritional requirements and must suction or spit out their saliva to prevent aspiration and a sensation of asphyxiation. Despite these precautions, many of these patients ultimately suffer life-threatening pneumonia. Investigators will be testing if the use of use of a negative pressure suction in the hypopharynx will reduce the amount of aspiration during Video Fluoroscopic Swallowing Exam (VFSE) among patients with severe oropharyngeal dysphagia

Connect with a study center

  • UC Davis Medical Center

    Sacramento, California 95817
    United States

    Active - Recruiting

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