A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

Inclusion Criteria:

• Confirmed diagnosis of CD for at least 3 months prior to Baseline.
• Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF),abdominal pain (AP) score.
• Evidence of mucosal inflammation based on the Simplified Endoscopic Score for Crohn'sdisease (SES-CD) on an endoscopy confirmed by a central reader.
• Demonstrated an inadequate response or intolerance to one or more conventional and/orbiologic therapies (oral locally acting steroids, intravenous or oral corticosteroids,immunosuppressants or biologic therapies for CD), in the opinion of the investigator.
• Note: Participants who have had inadequate response or intolerance toconventional therapy who have received prior biologic may be enrolled; however,participants must have discontinued the biologic for reasons other thaninadequate response or intolerance (e.g., change of insurance, well controlleddisease).
• If female, participant must meet the contraception recommendations.

Exclusion Criteria:

• Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
• Participant not on stable doses of CD related antibiotics, oral aminosalicylates,corticosteroids or methotrexate (MTX).
• Participant with the following ongoing known complications of CD: abscess (abdominalor peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, > 2entire missing segments of the following 5 segments: terminal ileum, right colon,transverse colon, sigmoid and left colon, and rectum, or any other manifestation thatmight require surgery while enrolled in the study.
• Participant with ostomy or ileoanal pouch.
• Participant diagnosed with conditions that could interfere with drug absorptionincluding but not limited to short gut or short bowel syndrome.
• Screening laboratory and other analyses show abnormal results.