Role of LDH as a Predictor of Treatment Outcomes in Hepatocellular Carcinoma

Last updated: November 7, 2017
Sponsor: Assiut University
Overall Status: Trial Status Unknown

Phase

N/A

Condition

Hepatic Fibrosis

Liver Cancer

Digestive System Neoplasms

Treatment

N/A

Clinical Study ID

NCT03338166
URL
  • Ages 18-65
  • All Genders

Study Summary

Hepatocellular carcinoma represents the commonest primary cancer of the liver.serum lactate dehydrogenase is an indirect marker of tumor hypoxia,angioneogenesis and worse prognosis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients with Hepatocellular carcinoma diagnosed by biopsy or imaging criteria andalpha feto protein.

  • signed informed consent before registration in study

  • Eastern Cooperative oncology Groups Performance status between 0 and 2.

Exclusion

Exclusion Criteria:

  • Cachexia or poor condition

  • pregnant or human chorionic gonadotropin positive

  • patient with another liver tumor

  • Any previous treatment

Study Design

Total Participants: 50
Study Start date:
January 02, 2018
Estimated Completion Date:
December 31, 2018

Study Description

Hepatocellular carcinoma (HCC) represents the commonest primary cancer of the liver. Incidence is increasing and HCC has risen to become the 5th commonest malignancy worldwide and the third leading cause of cancer related death, exceeded only by cancers of the lung and stomach. HCC prevalence is higher in sub-Saharan Africa, central and Southeast Asia.Serum lactate dehydrogenase (LDH) levels is an indirect marker of tumor hypoxia, angioneogenesis and worse prognosis. Lactic dehydrogenase (LDH), which is a glycolytic enzyme, composed of four polypeptide chains, each one encoded by separate gene (M and H), exists in various types of human tissue and neoplasms. LDH is a key enzyme in the conversion pyruvate to lactate under anaerobic conditions .Five isoforms of LDH have been identified as a result of the five different combinations of polypeptide subunits.

Hypoxia represents a clinical biological mechanism for treatment resistance in cancer cells via the formation of new blood vessels. Furthermore, a growing body of evidence indicates that hypoxia might actually promote cancer development.