Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy

Phase

N/A

Condition

Memory Problems

Memory Loss

Mood Disorders

Treatment

N/A

Clinical Study ID

NCT03335696

MSD/IDREC/C1/2011/71

All Genders
Accepts Healthy Volunteers

Study Summary

Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Member of Whitehall II cohort attending at UCL for phase 11

Exclusion

Exclusion Criteria:

Not suitable for MRI, travelling to Oxford, seriously physically ill

Study Design

January 01, 2012

June 30, 2017

Study Description

A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.

Connect with a study center

University of Oxford
Oxford, England OX3 7JX
United Kingdom
Site Not Available

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