A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma

Inclusion Criteria:

Cohort 1: Advanced Pancreatic Cancer Cohort Inclusion Criteria

• Radiological, histological or cytological confirmed diagnosis of locally advanced ormetastatic pancreatic adenocarcinoma by the enrolling institution

• Patient planning to receive systemic treatment

• Hemoglobin > 8

• ECOG performance status 0-2

• A minimum age of 18 years old

• Willing to undergo a tumor biopsy

• Willing to provide permission to obtain banked tumor tissue for analysis (previousbiopsies or surgical material).

Cohort 2: Operable Pancreatic Cancer Cohort Inclusion Criteria

• Radiological, histological or cytological confirmed diagnosis of pancreaticadenocarcinoma by the enrolling institution

• Patient planned to undergo upfront resection

• No pre-operative systemic therapy nor chemoradiation therapy planned

• Hemoglobin > 8

• ECOG performance status 0-2

• A minimum age of 18 years old

• Willing to undergo a tumor biopsy

• Willing to provide permission to obtain banked tumor tissue for analysis (previousbiopsies or surgical material).

Cohort 3: Acute Benign Pancreatic Pathology Control Inclusion Criteria

• Confirmed diagnosis of acute pancreatitis or other acute pancreatic pathology by theenrolling institution

• Hemoglobin > 8

• ECOG performance status 0-2

• A minimum age of 18 years old

Cohort 4: Chronic Benign Pancreatic Pathology Control Inclusion Criteria

• Confirmed diagnosis of chronic pancreatitis or other non-cystic chronic pancreaticpathology by the enrolling institution

• Hemoglobin > 8

• ECOG performance status 0-2

• A minimum age of 18 years old

Cohort 5: IPMN Control Inclusion Criteria

• Confirmed diagnosis of IPMN without high risk features by the enrolling institution

• A minimum age of 18 years old

Cohort 6: Pancreatic Cyst Control Inclusion Criteria

• Confirmed diagnosis of benign pancreatic cyst by the enrolling institution

• A minimum age of 18 years old

Cohort 7: Healthy Control Inclusion Criteria

• A minimum age of 18 years old

Exclusion Criteria:

Cohort 1: Advanced Pancreatic Cancer Cohort Exclusion Criteria

• Prior chemotherapy or radiation therapy for pancreatic cancer within the last 3months in the localized setting

• Active second malignancy, unless low grade malignancy

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures

Cohort 2: Operable Pancreatic Cancer Cohort Exclusion Criteria

• Neoadjuvant chemotherapy or radiation therapy is planned

• Active second malignancy, unless low grade malignancy

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures

Cohort 3: Acute Benign Pancreatic Pathology Control Exclusion Criteria

• Active or prior malignancy, except prior non-melanoma skin cancer

• Proven to be a carrier of a cancer susceptibility gene or family history concerningfor genetic predisposition to cancer

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures

Cohort 4: Chronic Benign Pancreatic Pathology Control Exclusion Criteria

• Active or prior malignancy, except prior non-melanoma skin cancer

• Proven to be a carrier of a cancer susceptibility gene or family history concerningfor genetic predisposition to cancer

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures

Cohort 5: IPMN Control Exclusion Criteria

• IPMN with high risk features or planned resection

• Active or prior malignancy, except prior non-melanoma skin cancer

• Proven to be a carrier of a cancer susceptibility gene or family history concerningfor genetic predisposition to cancer

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures

Cohort 6: Pancreatic Cyst Control Exclusion Criteria

• Active or prior malignancy, except prior non-melanoma skin cancer

• Proven to be a carrier of a cancer susceptibility gene or family history concerningfor genetic predisposition to cancer

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures

Cohort 7: Healthy Control Exclusion Criteria

• Active or prior malignancy, except prior non-melanoma skin cancer

• Proven to be a carrier of a cancer susceptibility gene or family history concerningfor genetic predisposition to cancer

• Any medical or psychiatric condition that may interfere with ability to comply withprotocol procedures