Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease

Last updated: October 29, 2017
Sponsor: National Taiwan University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT03324022
201412026RINB
  • Ages 20-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Graves' orbitopathy (GO) affects about 50% of patients with Graves' disease (GD), and some cannot be cured by current treatments. Orbital fibroblasts involves in the pathogenesis of GO by producing glycosaminoglycans and inflammatory cytokines. Since fibroblast growth factors (FGFs) binding to FGF receptors (FGFRs) can induce proliferation and differentiation of fibroblasts, investigators would like to measure the expression of FGFs and FGFRs in GO patients to see if inhibition of FGF-FGFR pathway has potential in treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosed as thyroid eye disease

  • suggested to accept orbital decompression

Exclusion

Exclusion Criteria:

  • age below 20 or above 80

  • pregnancy

Study Design

Total Participants: 80
Study Start date:
December 25, 2014
Estimated Completion Date:
December 25, 2020

Connect with a study center

  • National Taiwan University Hospital Taipei, Taiwan

    Taipei,
    Taiwan

    Active - Recruiting

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