Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia

Inclusion Criteria:

• Adult or pediatric patient suffering from drug-resistant focal epilepsy;

• Age more than 2 years old;

• Brain MRI suggestive of FCD or normal;

• Standardized presurgical evaluation available including medical history, scalpvideo-EEG, 3T MRI, FDG-PET, Neuropsychological tests;

• Inpatient in one of the participating centers for recording seizure during long termscalp video-EEG and / or SEEG-monitoring;

• Resective surgery with a minimal post-operative follow-up of 12 months;

• Histopathologic evidence for FCD or non-pathologic findings (normal histology or mMCDtype II).

• Patient, parents or legally representative who have given written informed consent toallow the study data collection procedures.

Exclusion Criteria:

• Brain MRI suggestive of another type of lesion;

• Difficulty to read or understand French, or inability to understand the information;

• Pregnant or breastfeeding woman;

• Subject under judicial protection.

• Other lesion discovered on histological examination;

• FCD type 3, dual pathology, ambiguous or unavailable neuropathological findings

• Lack of longitudinal pre- and post-surgical follow-up.