Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease

Last updated: November 28, 2023
Sponsor: University of Colorado, Denver
Overall Status: Active - Recruiting

Phase

N/A

Condition

Musculoskeletal Diseases

Dermatomyositis (Connective Tissue Disease)

Arthritis And Arthritic Pain

Treatment

N/A

Clinical Study ID

NCT03297775
16-1097
  • Ages 45-90
  • All Genders

Study Summary

The overall goal of this study is to define the phenotype of Interstitial Lung Disease (ILD), and identify factors that predict radiologic progression in those with subclinical RA-ILD, in patients with rheumatoid arthritis (RA). The investigators hypothesize that there are common core elements (e.g. clinical features, genetic variants, and/or biologic markers) between other forms of ILD (e.g. idiopathic pulmonary fibrosis, IPF) and subclinical RA-ILD that places individuals at risk for the development of lung disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. ≥ 45years old
  2. Diagnosis of RA using the 2010 American College of Rheumatology (ACR) criteria

Exclusion

Exclusion Criteria:

  1. Inability to give informed consent
  2. Pregnant women
  3. History of interstitial lung disease
  4. Evidence of other causes of diffuse parenchymal lung disease such as infection, drugtoxicity, other autoimmune processes, etc.
  5. Subjects over the age of 90 years old or less than 45 years old

Study Design

Total Participants: 750
Study Start date:
June 22, 2017
Estimated Completion Date:
June 30, 2027

Connect with a study center

  • University of Colorado - Anschutz Medical Campus

    Aurora, Colorado 80045
    United States

    Active - Recruiting

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