Progestrone and Doppler Indices

Last updated: October 10, 2017
Sponsor: Kasr El Aini Hospital
Overall Status: Completed

Phase

2/3

Condition

Pregnancy

Pregnancy Complications

Miscarriage

Treatment

N/A

Clinical Study ID

NCT03292939
7880
  • Ages 18-40
  • Female

Study Summary

The aim of our study is to assess the effect of vaginal progestrone on fetal and maternal doppler indices

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Gestational age: 18-33 weeks

  • Willing and able to give informed consent

  • History of preterm labor (<34 weeks)

  • At risk for preterm labor ( increased amniotic fluid volume)

  • Short cervical length (<25mm) as incidental finding

  • Presenting with actual cervical changes ( dilatation and\or effacement) in currentpregnancy

Exclusion

Exclusion Criteria:

  • PPROM

  • Contraindication to progesterone use

  • Diabetic patients, have glucose intolerance

  • Multiple pregnancies

Study Design

Total Participants: 80
Study Start date:
January 01, 2017
Estimated Completion Date:
October 01, 2017

Study Description

A complete Doppler flow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the first administration of 400mg of vaginal progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine,equipped with a 3.5- MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.

Connect with a study center

  • Kasr El Ainiy Hospital

    Cairo, 11562
    Egypt

    Site Not Available

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