Integrative Medicine for Chemotherapy-Induced Peripheral Neuropathy

Last updated: August 21, 2024
Sponsor: The Chaim Sheba Medical Center
Overall Status: Completed

Phase

N/A

Condition

Neurologic Disorders

Treatment

Multi-modality (Acupuncture "plus")

Acupuncture

Clinical Study ID

NCT03290976
4462-17-SMC
  • Ages > 18
  • All Genders

Study Summary

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often debilitating complication of cancer treatments. There is presently no known treatment which can prevent the onset of CIPN, with treatment of existing symptoms limited to reducing the dose intensity of the offending agent. Clinical research has shown that complementary/integrative medicine (CIM) modalities such as acupuncture and reflexology may be effective in relieving CIPN-related symptoms. The present study will included 120 patients suffering from CIPN-related symptoms, and will take place at 3 medical centers in Israel which provide CIM treatments to oncology and hemato-oncology patients. Participants will be allocated to either the control arm (standard conventional supportive care; n=40) or to the intervention arm of the study (standard care with CIM treatments; n=80), based on their preference. Patients in the treatment arm of the study will be randomly allocated to either twice-weekly, single modality acupuncture treatments (n=40), or to a multi-modality treatment program (n=40), which will include acupuncture and additional CIM modalities (i.e., manual-movement and mind-body therapies), for a 6-week period.

The effect of CIM treatments in reducing the severity of CIPN-related symptoms will be assessed at baseline and at 6- and 9-week follow-up visits, using the Functional Assessment of Cancer Therapy -Taxane (FACT-Tax) tool; the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - C30 (EORTC QLQ-C30); and the Measure Yourself Concerns and Well-being (MYCAW) questionnaire. Interim assessment of symptom severity will be conducted by the study nurse throughout the study period, through either telephone or e-mail. Additional study outcomes will include the safety of the CIM treatments; QOL-related concerns which may affect CIPN-related symptoms (e.g., anxiety, depression, sleep disturbances, etc.), as well as issues related to body image and coping with CIPN; physiological assessment of CIPN using a von Frey test (with hairs of varying diameters to assess the threshold for touch evoked sensations); and adherence to the planned oncology treatment regimen, as measured by the Relative Dose Intensity (RDI) calculation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Female patients with breast or gynecological cancers who are undergoing a treatmentregimen which includes taxane-based chemotherapy (e.g., Paclitaxel, Docetaxel); or

  • Patients of either gender with hematological malignancies who are undergoing atreatment regimen which includes neuropathy-inducing agents (e.g., bortezumab formultiple myeloma, etc.).

  • Eligible patients will report altered sensations and/or pain in the areas of thefeet and or hands, with a score of ≥ 2 (moderate-to-severe) for chemotherapy-inducedperipheral neuropathy on the National Cancer Institute (NCI) Common ToxicityCriteria for Adverse Events - version 4.0 (CTC-AE.v-4.0)

  • The onset of CIPN-related symptoms must be recent, following a recently-administeredcourse of chemotherapy and with symptoms appearing no more than a month prior tostudy recruitment.

Patients must be able to comply with the study protocol, which includes weekly follow-up visits, either in person or by phone; completion of the study questionnaires, in accordance with the study protocol; and, for patients in the treatment arm of the study, attending twice-weekly CIM treatment sessions.

Exclusion

Exclusion Criteria:

  • Patients not fulfilling the inclusion criteria, or those with a history of chronicmedical conditions which predispose to the development of CIPN (e.g., diabetesmellitus, alcohol abuse), will be ineligible for participation in the study.

Study Design

Total Participants: 168
Treatment Group(s): 2
Primary Treatment: Multi-modality (Acupuncture "plus")
Phase:
Study Start date:
March 01, 2018
Estimated Completion Date:
May 31, 2021

Connect with a study center

  • Chaim Sheba Medical Center

    Ramat Gan, 52621
    Israel

    Site Not Available

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