Optimal Strategy of Primary PCI for Left Main Coronary Artery Occlusion Induced AMI

Last updated: November 18, 2017
Sponsor: Shanghai Zhongshan Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cardiac Disease

Circulation Disorders

Myocardial Ischemia

Treatment

N/A

Clinical Study ID

NCT03282773
B2017-104
  • Ages 18-80
  • All Genders

Study Summary

This study will compare clinical outcomes of immediate stent implantation with deferred stent implantation(4-10days after primary angiography) for patients presented with acute myocardial infarction due to left main coronary artery occlusion.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of acute myocardial infarction occured within 12 hours

  • Left main coronary artery occlusion confirmed by angiography

  • Left main coronary artery occlusion (TIMI flow 0,1 or 2) confirmed by primaryangiography, TIMI flow grade 3 achieved after pretreatment of thrombus aspiration orballoon dilatation

Exclusion

Exclusion Criteria:

  • Life expectancy less than 1 years

  • Cardiogenic shock

  • Chronic kidney disease, stage 4 by KDOQI(GFR<30ml/min)

  • Contraindications to aspirin or other anti-platelet drugs

  • Allergy to contrast agent, rapamycin or paclitaxel

  • Patients who are included in other ongoing trials

  • Pregnant female

Study Design

Total Participants: 480
Study Start date:
November 01, 2017
Estimated Completion Date:
July 31, 2022

Study Description

Primary percutaneous coronary intervention for patients presented with acute myocardial infarction caused by left main coronary artery occlusion is associated with significantly higher mortality and risks of major cardiac adverse events. Deferred stent implantation may improve prognosis of primary PCI through reducing distal embolization and no-reflow phenomenon. There is no randomized clinical trial focuses on the effect and outcome of deferred stent implantation on primary PCI for left main coronary artery occlusion in contrast with conventional strategy.

This prospective, multicenter, randomized trial is aimed to compare immediate stenting with deferred stenting for LM-AMI with 30 centers in China involved. We hope to determine whether deferred stenting is superior to conventional strategy for primary PCI of AMI caused by left main coronary artery occlusion in improving long-term clinical outcomes and cardiac function.

Connect with a study center

  • Zhongshan Hospital

    Shanghai, Shanghai 200032
    China

    Active - Recruiting

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