Transcranial Magnetic Stimulation (TMS) for Motor Symptoms in Psychiatric Disorders

Phase

N/A

Condition

Depression (Major/severe)

Tourette's Syndrome

Mood Disorders

Treatment

N/A

Clinical Study ID

NCT03275766

SNCTP610

Ages 18-65
All Genders

Study Summary

Psychomotor slowing may occur in major psychiatric disorders, such as major depressive disorders or schizophrenia spectrum disorders. It refers to slowing of fine motor skills, motor planning and gross motor behavior. In major depression and schizophrenia, psychomotor slowing is associated with alterations of premotor cortex, dorsolateral prefrontal cortex and basal ganglia. This randomized, sham-controlled, prospective trial will test, whether 15 sessions of repetitive transcranial magnetic stimulation (rTMS) may ameliorate psychomotor slowing in schizophrenia or major depression.

Eligibility Criteria

Inclusion

Inclusion Criteria:

suffering from major depressive disorder or schizophrenia spectrum disorder accordingto DSM-5 criteria
right handedness
normal or corrected-to-normal vision and hearing

Exclusion

Exclusion Criteria:

epilepsy
history of severe head trauma
current abuse of drugs or alcohol; past addiction to drugs or alcohol
pregnancy
incompatibility to cerebral MRI

Study Design

June 01, 2016

July 15, 2019

Study Description

Psychomotor slowing may occur in major psychiatric disorders, such as major depressive disorders or schizophrenia spectrum disorders. It refers to slowing of fine motor skills, motor planning and gross motor behavior. In major depression and schizophrenia, psychomotor slowing is associated with alterations of premotor cortex, dorsolateral prefrontal cortex and basal ganglia. This randomized, sham-controlled, prospective trial will test, whether 15 sessions of rTMS in 3 weeks may ameliorate psychomotor slowing in schizophrenia or major depression.

Eligible participants will be randomized to one of four arms:

Connect with a study center

University Hospital of Psychiatry, University of Bern
Bern, 3008
Switzerland
Site Not Available

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