Last updated: August 4, 2021
Sponsor: University of Miami
Overall Status: Completed
Phase
2
Condition
High Blood Pressure (Hypertension)
Lung Disease
Occlusions
Treatment
N/AClinical Study ID
NCT03270332
20170552
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- A Mean Pulmonary Artery Pressure >25mmHg, Pulmonary Vascular Resistance >3 wood/unitsand pulmonary arterial wedge pressure <15mmHg, as documented by right heartcatheterization within the last 3 years
- Regular use of oral pulmonary vasodilators
Exclusion
Exclusion Criteria:
- Presence of chronic respiratory disease (as documented by prior lung imaging andpulmonary function tests), cardiovascular disease (as documented by priorechocardiography and/or left heart catheterization), thromboembolic PAH (as documentedby pulmonary angiography)
- women of childbearing potential who do not use accepted birth- control measures
- pregnant and breast-feeding women
- respiratory infection within 4 weeks of testing
- A systemic systolic arterial BP> 150 and/or diastolic arterial BP>100 on theexperiment day
- A resting O2 saturation of < 90%
- Current smoking
- BMI >35 kg/m2 and/or a diagnosis of obstructive sleep apnea
- Use of inhaled or intravenous pulmonary vasodilators
Study Design
Total Participants: 10
Study Start date:
October 05, 2017
Estimated Completion Date:
July 02, 2020
Connect with a study center
University of Miami
Miami, Florida 33136
United StatesSite Not Available
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