Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCHCD3)

Inclusion Criteria:

1. ≥ 18 years old.

2. Medical record documentation of recurrent CDI per the study definition, thatincludes either: a) at least one recurrence after a primary episode and hascompleted at least one round of standard-of-care oral antibiotic therapy or b) hashad at least two episodes of severe CDI resulting in hospitalization within the lastyear.

3. A positive stool test for the presence of toxigenic C. difficile within 30 daysprior to or on the date of enrollment.

4. Is currently taking or was just prescribed antibiotics to control CDI relateddiarrhea at the time of enrollment.

[Note: Subject's CDI diarrhea must be controlled (<3 unformed/loose stools/day) while taking this course of antibiotics]

Exclusion Criteria:

1. Currently has continued CDI diarrhea despite being on antibiotics prescribed for CDItreatment.

2. Previous fecal transplant

3. History of inflammatory bowel disease (IBD), e.g., ulcerative colitis, Crohn'sdisease, or microscopic colitis.

4. Diagnosis of irritable bowel syndrome (IBS) as determined by Rome III criteria.

5. Compromised immune system (e.g. immunosuppressed due to a medical condition ormedication; current or recent (< 90 days) treatment with chemotherapy)

6. An absolute neutrophil count of <1000 cells/µL during screening.

7. Pregnant, breastfeeding, or intends to become pregnant during study participation.