Phase
Condition
Diabetes And Hypertension
Diabetes Mellitus, Type 2
Diabetes Prevention
Treatment
N/AClinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion criteria :
- Participants with Type 2 Diabetes (drug-naïve or on antidiabetic therapy) anddocumented moderate renal insufficiency defined by an estimated glomerular filtrationrate (eGFR) (based on the 4 variable Modification of Diet in Renal Disease (MDRD)equation) of ≥30 and <60 milliliter per minute (mL/min)/1.73 meter square (m^2) (chronic kidney disease [CKD] 3A, 3B).
- Participants has given written informed consent to participate in the study inaccordance with local regulations.
Exclusion
Exclusion criteria:
- Hemoglobin A1c (HbA1c) of <7.0% or >11.0%.
- Type 1 diabetes.
- Women of childbearing potential (WOCBP) not willing to use highly effective method(s)of birth control during the study treatment period and the follow-up period, or whoare unwilling or unable to be tested for pregnancy during the study.
- Treatment with a sodium-glucose cotransporter type 2 (SGLT2) inhibitor (Canagliflozin,Dapagliflozin, Empagliflozin) during the last 12 months.
- Uncontrolled high blood pressure.
- Participants with severe anemia, severe cardiovascular (including congestive heartfailure New York Heart Association IV), respiratory, hepatic, neurological,psychiatric, or active malignant tumor or other major systemic disease or patientswith short life expectancy that, according to the Investigator, will preclude theirsafe participation in this study, or will make implementation of the protocol orinterpretation of the study results difficult.
- Lower extremity complications (such as skin ulcers, infection, osteomyelitis andgangrene) identified during the Screening period, and still requiring treatment atRandomization. The above information is not intended to contain all considerations relevant to aparticipant's potential participation in a clinical trial.
Study Design
Study Description
Connect with a study center
Investigational Site Number 0324001
Buenos Aires, C1429BWN
ArgentinaSite Not Available
Investigational Site Number 0324002
Caba, 1425DES
ArgentinaSite Not Available
Investigational Site Number 0324005
Ciudad Autónoma Buenos Aires, 1205
ArgentinaSite Not Available
Investigational Site Number 0324008
Cordoba, 5000
ArgentinaSite Not Available
Investigational Site Number 0324004
Coronel Suarez, B7540GHD
ArgentinaSite Not Available
Investigational Site Number 0324006
Córdoba, X5008HHW
ArgentinaSite Not Available
Investigational Site Number 0324009
La Plata, 1900
ArgentinaSite Not Available
Investigational Site Number 0324003
Lanus, B1824KAJ
ArgentinaSite Not Available
Investigational Site Number 0324007
Mar Del Plata, B7600FYK
ArgentinaSite Not Available
Investigational Site Number 0764007
Belo Horizonte, 30150-240
BrazilSite Not Available
Investigational Site Number 0764001
Belém, 66073-005
BrazilSite Not Available
Investigational Site Number 0764002
Curitiba, 80030-480
BrazilSite Not Available
Investigational Site Number 0764008
Curitiba, 80810-040
BrazilSite Not Available
Investigational Site Number 0764003
Fortaleza, 60170-195
BrazilSite Not Available
Investigational Site Number 0764005
Rio De Janeiro, 22271-100
BrazilSite Not Available
Investigational Site Number 0764006
Sao Paulo, 04266-010
BrazilSite Not Available
Investigational Site Number 0764004
São Paulo, 01244-030
BrazilSite Not Available
Investigational Site Number 1244007
Brampton, L6S 0C6
CanadaSite Not Available
Investigational Site Number 1244004
Burlington, L7R 1A4
CanadaSite Not Available
Investigational Site Number 1244005
Etobicoke, M9R 4E1
CanadaSite Not Available
Investigational Site Number 1244006
Laval, H7T 2P5
CanadaSite Not Available
Investigational Site Number 1244009
Montreal, H4A 2C6
CanadaSite Not Available
Investigational Site Number 1244010
Ottawa, K2J 0V2
CanadaSite Not Available
Investigational Site Number 1244003
Thornhill, L4J 8L7
CanadaSite Not Available
Investigational Site Number 1244002
Toronto, M4C 5T2
CanadaSite Not Available
Investigational Site Number 1244008
Toronto, M4G 3E8
CanadaSite Not Available
Investigational Site Number 1244001
Vancouver, V5Y 3W2
CanadaSite Not Available
Investigational Site Number 1704007
Barranquilla, 80020
ColombiaSite Not Available
Investigational Site Number 1704008
Barranquilla, 080001
ColombiaSite Not Available
Investigational Site Number 1704004
Bogota, 110221
ColombiaSite Not Available
Investigational Site Number 1704009
Bogota, 110911
ColombiaSite Not Available
Investigational Site Number 1704006
Ibague, 730006
ColombiaSite Not Available
Investigational Site Number 1704001
Manizales, 170004
ColombiaSite Not Available
Investigational Site Number 1704002
Medellin / Antioquia, 50021
ColombiaSite Not Available
Investigational Site Number 1704005
Zipaquira, 250252
ColombiaSite Not Available
Investigational Site Number 2764001
Frankfurt Am Main, 60596
GermanySite Not Available
Investigational Site Number 2764002
Hamburg, 21073
GermanySite Not Available
Investigational Site Number 2764003
Muenster, 48145
GermanySite Not Available
Investigational Site Number 2764003
Münster, 48145
GermanySite Not Available
Investigational Site Number 3484008
Baja, 6500
HungarySite Not Available
Investigational Site Number 3484012
Baja, 6500
HungarySite Not Available
Investigational Site Number 3484002
Balatonfured, 8230
HungarySite Not Available
Investigational Site Number 3484007
Budapest, 1033
HungarySite Not Available
Investigational Site Number 3484005
Debrecen, 4032
HungarySite Not Available
Investigational Site Number 3484011
Debrecen, 4025
HungarySite Not Available
Investigational Site Number 3484001
Gyula, 5700
HungarySite Not Available
Investigational Site Number 3484010
Nyiregyhaza, 4405
HungarySite Not Available
Investigational Site Number 3484013
Nyregyhza, 4400
HungarySite Not Available
Investigational Site Number 3484004
Pécs, 7623
HungarySite Not Available
Investigational Site Number 3764001
Ashkelon, 7830604
IsraelSite Not Available
Investigational Site Number 3764010
Be'Er-Sheva, 84101
IsraelSite Not Available
Investigational Site Number 3764013
Be'er Ya'aqov, 70300
IsraelSite Not Available
Investigational Site Number 3764007
Haifa, 31096
IsraelSite Not Available
Investigational Site Number 3764009
Kfar-Saba, 44281
IsraelSite Not Available
Investigational Site Number 3764011
Kfar-Saba, 44281
IsraelSite Not Available
Investigational Site Number 3764003
Nahariya, 22100
IsraelSite Not Available
Investigational Site Number 3764004
Petach Tikva, 49100
IsraelSite Not Available
Investigational Site Number 3764006
Ramat Gan, 52621
IsraelSite Not Available
Investigational Site Number 3764005
Rehovot, 76100
IsraelSite Not Available
Investigational Site Number 3764002
Tel Aviv, 61480
IsraelSite Not Available
Investigational Site Number 3764008
Zefat, 13100
IsraelSite Not Available
Investigational Site Number 3764013
Zerifin, 70300
IsraelSite Not Available
Investigational Site Number 3804007
Catania, 95123
ItalySite Not Available
Investigational Site Number 3804004
Milano, 20132
ItalySite Not Available
Investigational Site Number 3804005
Milano, 20122
ItalySite Not Available
Investigational Site Number 3804008
Naples, 80131
ItalySite Not Available
Investigational Site Number 3804002
Napoli, 80138
ItalySite Not Available
Investigational Site Number 3804001
Pavia, 27100
ItalySite Not Available
Investigational Site Number 3804003
Roma, 00168
ItalySite Not Available
Investigational Site Number 3804003
Rome, 00168
ItalySite Not Available
Investigational Site Number 3804006
Siena, 53100
ItalySite Not Available
Investigational Site Number 4844009
Chihuahua Chihuahua, 31217
MexicoSite Not Available
Investigational Site Number 4844008
Durango, Durango, 34080
MexicoSite Not Available
Investigational Site Number 4844001
Guadalajara, 44210
MexicoSite Not Available
Investigational Site Number 4844003
Guadalajara, 44600
MexicoSite Not Available
Investigational Site Number 4844006
Merida, Yucatan, 97130
MexicoSite Not Available
Investigational Site Number 4844005
Monterrey, 64460
MexicoSite Not Available
Investigational Site Number 4844006
Mérida, 97130
MexicoSite Not Available
Investigational Site Number 4844004
Xalapa, 91020
MexicoSite Not Available
Investigational Site Number 6164002
Bia?Ystok, 15-435
PolandSite Not Available
Investigational Site Number 6164002
Białystok, 15-435
PolandSite Not Available
Investigational Site Number 6164006
Katowice, 40-081
PolandSite Not Available
Investigational Site Number 6164004
Krakow, 31-209
PolandSite Not Available
Investigational Site Number 6164008
Krakow, 31-530
PolandSite Not Available
Investigational Site Number 6164009
Krakow, 30-363
PolandSite Not Available
Investigational Site Number 6164010
Krakow, 30-033
PolandSite Not Available
Investigational Site Number 6164011
Lodz, 92-213
PolandSite Not Available
Investigational Site Number 6164005
Oswiecim, 32-600
PolandSite Not Available
Investigational Site Number 6164003
Rzeszow, 35-055
PolandSite Not Available
Investigational Site Number 6164012
Skierniewice, 96-100
PolandSite Not Available
Investigational Site Number 6164007
Warszawa, 02-507
PolandSite Not Available
Investigational Site Number 6424001
Bacau, 600238
RomaniaSite Not Available
Investigational Site Number 6424002
Bacau, 600154
RomaniaSite Not Available
Investigational Site Number 6424009
Bucure?Ti, 013764
RomaniaSite Not Available
Investigational Site Number 6424004
Bucuresti, 010825
RomaniaSite Not Available
Investigational Site Number 6424009
Bucuresti, 013764
RomaniaSite Not Available
Investigational Site Number 6424010
Bucuresti, 040172
RomaniaSite Not Available
Investigational Site Number 6424006
Hunedoara, 331057
RomaniaSite Not Available
Investigational Site Number 6424007
Ia?I, 700503
RomaniaSite Not Available
Investigational Site Number 6424011
Oradea, 410159
RomaniaSite Not Available
Investigational Site Number 6424003
Targu-Mures, 540142
RomaniaSite Not Available
Investigational Site Number 6434003
Chelyabinsk, 454047
Russian FederationSite Not Available
Investigational Site Number 6434005
Kemerovo, 650002
Russian FederationSite Not Available
Investigational Site Number 6434002
Krasnodar, 3500
Russian FederationSite Not Available
Investigational Site Number 6434004
Novosibirsk, 630091
Russian FederationSite Not Available
Investigational Site Number 6434001
St. Petersburg, 194358
Russian FederationSite Not Available
Investigational Site Number 6434006
Yaroslavl, 150003
Russian FederationSite Not Available
Investigational Site Number 7104002
Cape Town, 7570
South AfricaSite Not Available
Investigational Site Number 7104008
Cape Town, 7531
South AfricaSite Not Available
Investigational Site Number 7104007
Goodwood, 7463
South AfricaSite Not Available
Investigational Site Number 7104001
Johannesburg, 1685
South AfricaSite Not Available
Investigational Site Number 7104005
Johannesburg, 2198
South AfricaSite Not Available
Investigational Site Number 7104010
Johannesburg, 2188
South AfricaSite Not Available
Investigational Site Number 7104004
Parow, 7500
South AfricaSite Not Available
Investigational Site Number 7104006
Pretoria, 0002
South AfricaSite Not Available
Investigational Site Number 7104009
Pretoria Gauteng, 0181
South AfricaSite Not Available
Investigational Site Number 7104011
Worcester, 6850
South AfricaSite Not Available
Investigational Site Number 7244011
Barcelona, 08035
SpainSite Not Available
Investigational Site Number 7244007
Granada, 18012
SpainSite Not Available
Investigational Site Number 7244003
Madrid, 28041
SpainSite Not Available
Investigational Site Number 7244003
Madrid Madrid, 28041
SpainSite Not Available
Investigational Site Number 7244010
Málaga Málaga, 29010
SpainSite Not Available
Investigational Site Number 7244006
Palma De Mallorca, 07010
SpainSite Not Available
Investigational Site Number 7244008
Sabadell, Barcelona, 8208
SpainSite Not Available
Investigational Site Number 7244001
Sevilla, 41071
SpainSite Not Available
Investigational Site Number 7244002
Valencia, 46014
SpainSite Not Available
Investigational Site Number 7244002
Valencia Valencia, 46014
SpainSite Not Available
Investigational Site Number 7244009
Zaragoza, 50009
SpainSite Not Available
Investigational Site Number 8044004
Dnipro,
UkraineSite Not Available
Investigational Site Number 8044004
Dnipropetrovsk, 49005
UkraineSite Not Available
Investigational Site Number 8044007
Kharkiv, 61106
UkraineSite Not Available
Investigational Site Number 8044010
Kharkiv, 61166
UkraineSite Not Available
Investigational Site Number 8044007
Kharkov,
UkraineSite Not Available
Investigational Site Number 8044003
Kiev, 04050
UkraineSite Not Available
Investigational Site Number 8044008
Kiev, 02002
UkraineSite Not Available
Investigational Site Number 8044001
Kyiv, 03037
UkraineSite Not Available
Investigational Site Number 8044006
Kyiv, 03049
UkraineSite Not Available
Investigational Site Number 8044009
Kyiv, 02091
UkraineSite Not Available
Investigational Site Number 8044005
Lviv, 79010
UkraineSite Not Available
Investigational Site Number 8044002
Zaporizhia, 69600
UkraineSite Not Available
Investigational Site Number 8404018
Birmingham, Alabama 35205
United StatesSite Not Available
Investigational Site Number 8404045
Guntersville, Alabama 35976-2206
United StatesSite Not Available
Investigational Site Number 8404004
Phoenix, Arizona 85018-2701
United StatesSite Not Available
Investigational Site Number 8404022
Phoenix, Arizona 85050-7500
United StatesSite Not Available
Investigational Site Number 8404007
Little Rock, Arkansas 72205
United StatesSite Not Available
Investigational Site Number 8404023
Chula Vista, California 91910
United StatesSite Not Available
Investigational Site Number 8404044
Gold River, California 95670
United StatesSite Not Available
Investigational Site Number 8404011
Los Angeles, California 90057
United StatesSite Not Available
Investigational Site Number 8404003
Norco, California 92860
United StatesSite Not Available
Investigational Site Number 8404025
Northridge, California 91324
United StatesSite Not Available
Investigational Site Number 8404038
San Dimas, California 91713
United StatesSite Not Available
Investigational Site Number 8404017
Colorado Springs, Colorado 80920-8075
United StatesSite Not Available
Investigational Site Number 8404019
Clearwater, Florida 33761
United StatesSite Not Available
Investigational Site Number 8404001
DeLand, Florida 32720-0834
United StatesSite Not Available
Investigational Site Number 8404006
Ocoee, Florida 34761-4547
United StatesSite Not Available
Investigational Site Number 8404064
Orlando, Florida 32806
United StatesSite Not Available
Investigational Site Number 8404043
Ormond Beach, Florida 32174-8187
United StatesSite Not Available
Investigational Site Number 8404013
Palmetto Bay, Florida 33157-5503
United StatesSite Not Available
Investigational Site Number 8404016
Savannah, Georgia 31406
United StatesSite Not Available
Investigational Site Number 8404040
Wauconda, Illinois 60084-2452
United StatesSite Not Available
Investigational Site Number 8404058
Sellersburg, Indiana 47172-8932
United StatesSite Not Available
Investigational Site Number 8404036
Lake Charles, Louisiana 70601
United StatesSite Not Available
Investigational Site Number 8404020
New Orleans, Louisiana 70119-6302
United StatesSite Not Available
Investigational Site Number 8404014
Norfolk, Nebraska 68701
United StatesSite Not Available
Investigational Site Number 8404032
Papillion, Nebraska 68046-3136
United StatesSite Not Available
Investigational Site Number 8404048
Hackensack, New Jersey 07601-1963
United StatesSite Not Available
Investigational Site Number 8404009
Bronx, New York 10455
United StatesSite Not Available
Investigational Site Number 8404074
New York, New York 00000
United StatesSite Not Available
Investigational Site Number 8404009
The Bronx, New York 10455
United StatesSite Not Available
Investigational Site Number 8404051
Wilmington, North Carolina 28401-6638
United StatesSite Not Available
Investigational Site Number 8404028
Winston-Salem, North Carolina 27103-3914
United StatesSite Not Available
Investigational Site Number 8404029
Winston-Salem, North Carolina 27103-4027
United StatesSite Not Available
Investigational Site Number 8404026
Dayton, Ohio 45419-4336
United StatesSite Not Available
Investigational Site Number 8404052
Lansdale, Pennsylvania 19446-1002
United StatesSite Not Available
Investigational Site Number 8404031
Anderson, South Carolina 29621
United StatesSite Not Available
Investigational Site Number 8404024
Charleston, South Carolina 29407
United StatesSite Not Available
Investigational Site Number 8404021
Mount Pleasant, South Carolina 29464
United StatesSite Not Available
Investigational Site Number 8404056
Chattanooga, Tennessee 37404
United StatesSite Not Available
Investigational Site Number 8404015
Austin, Texas 78726-4061
United StatesSite Not Available
Investigational Site Number 8404050
Austin, Texas 78731
United StatesSite Not Available
Investigational Site Number 8404060
Austin, Texas 78749
United StatesSite Not Available
Investigational Site Number 8404005
Beaumont, Texas 77702
United StatesSite Not Available
Investigational Site Number 8404035
Dallas, Texas 75208
United StatesSite Not Available
Investigational Site Number 8404039
Houston, Texas 77058
United StatesSite Not Available
Investigational Site Number 8404055
Houston, Texas 77099
United StatesSite Not Available
Investigational Site Number 8404012
Hurst, Texas 76054
United StatesSite Not Available
Investigational Site Number 8404033
Lampasas, Texas 76550-1820
United StatesSite Not Available
Investigational Site Number 8404053
McAllen, Texas 78504
United StatesSite Not Available
Investigational Site Number 8404057
Round Rock, Texas 78681
United StatesSite Not Available
Investigational Site Number 8404010
San Antonio, Texas 78249-2782
United StatesSite Not Available
Investigational Site Number 8404059
San Antonio, Texas 78212
United StatesSite Not Available
Investigational Site Number 8404008
Layton, Utah 84041-1200
United StatesSite Not Available
Investigational Site Number 8404042
Renton, Washington 98057
United StatesSite Not Available
Investigational Site Number 8404041
Seattle, Washington 98105
United StatesSite Not Available
Investigational Site Number 8404047
Kenosha, Wisconsin 53144
United StatesSite Not Available
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