Phase
Condition
Multiple Myeloma
Leukemia
Cancer/tumors
Treatment
Dexamethasone
Velcade
Daratumumab
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Documented multiple myeloma (MM) as defined by the criteria: monoclonal plasma cellsin the bone marrow greater than or equal to (>=) 10 percent (%) at some point in theparticipant's disease course or presence of a biopsy-proven plasmacytoma
Received at least 1 prior line of therapy for MM
Documented evidence of progressive disease (PD) based on investigator'sdetermination of response as defined by the International Myeloma Working Group (IMWG) criteria on or after their last regimen
Achieved a response (partial response [PR] or better based on investigator'sdetermination of response by the IMWG criteria) to at least 1 prior regimen
Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0, 1, or 2
Exclusion
Exclusion Criteria:
Received daratumumab or other anti-CD38 therapies
Refractory to Velcade, or another proteasome inhibitor (PI), like ixazomib andcarfilzomib (ie, participant had progression of disease while receiving Velcadetherapy or within 60 days of ending Velcade therapy, or another PI, like ixazomiband carfilzomib, etc)
Intolerant to Velcade (that is [ie], discontinued due to any adverse event while onVelcade treatment)
Planning to undergo a stem cell transplant prior to progression of disease on thisstudy, that is ie, these participants should not be enrolled in order to reducedisease burden prior to transplant
History of malignancy (other than MM) within 3 years before the date ofrandomization
Study Design
Connect with a study center
Peking Union Medical College Hospital
Beijing, 100032
ChinaSite Not Available
Peking University First Hospital
Beijing, 100034
ChinaSite Not Available
Peking University People s Hospital
Beijing, 100044
ChinaSite Not Available
Peking University People's Hospital
Beijing, 100044
ChinaSite Not Available
Peking University Third Hospital
Beijing, 100083
ChinaSite Not Available
The First Hospital of Jilin University
Changchun, 130021
ChinaSite Not Available
West China Hospital Si Chuan University
Chengdu, 610041
ChinaSite Not Available
West China Hospital, Si Chuan University
Chengdu, 610041
ChinaSite Not Available
Xinqiao Hospital of the Third Military Medical University
Chongqing, 400037
ChinaSite Not Available
Fujian Meidical University Union Hospital
Fuzhou, 350001
ChinaSite Not Available
Guangdong Provincial People's Hospital
Guangzhou, 510080
ChinaSite Not Available
Nanfang Hospital
Guangzhou, 510515
ChinaSite Not Available
The First Affiliated Hospital Sun Yat sen University
Guangzhou, 510080
ChinaSite Not Available
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, 510080
ChinaSite Not Available
First Affiliated Hospital Medical School of Zhejiang University
Hangzhou, 310020
ChinaSite Not Available
First Affiliated Hospital, Medical School of Zhejiang University
Hangzhou, 310020
ChinaSite Not Available
First affiliated Hospital of Zhejiang University
Hangzhou, 310020
ChinaSite Not Available
Jiangsu Province Hospital
Nanjing, 210029
ChinaSite Not Available
Nanjing Drum Tower Hospital
Nanjing, 210008
ChinaSite Not Available
Zhongda Hospital Southeast University
Nanjing, 210009
ChinaSite Not Available
Zhongda Hospital,Southeast University
Nanjing, 210009
ChinaSite Not Available
Ruijin Hospital Shanghai Jiao Tong University
Shanghai, 200025
ChinaSite Not Available
Ruijin Hospital, Shanghai Jiao Tong University
Shanghai, 200025
ChinaSite Not Available
Shanghai Changzheng Hospital
Shanghai, 200003
ChinaSite Not Available
First Affiliated Hospital SooChow University
Suzhou, 215006
ChinaSite Not Available
First Affiliated Hospital, SooChow University
Suzhou, 215006
ChinaSite Not Available
Institute of Hematology & Blood Diseases Hospital
Tianjin, 300320
ChinaSite Not Available
Institute of Hematology and Blood Diseases Hospital
Tianjin, 300320
ChinaSite Not Available
Tianjin Medical University General Hospital
Tianjin, 300052
ChinaSite Not Available
Tianjin cancer hospital
Tianjin, 300040
ChinaSite Not Available
Institute of Hematology & Blood Diseases Hospital
Tianjin, China, 300320
ChinaSite Not Available
Tongji Hospital, Tongji Medical College of HUST
Wuhan, 430030
ChinaSite Not Available
Tangdu Hospital
Xian, 710038
ChinaSite Not Available
Henan Cancer Hospital
Zhengzhou, 450008
ChinaSite Not Available
National Taiwan University Hospital
Taipei, 10048
TaiwanSite Not Available
Tri-Service General Hospital
Taipei, 11490
TaiwanSite Not Available
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