C-arm Cone Beam CT Perfusion Guided Cerebrovascular Interventions

Last updated: May 24, 2022
Sponsor: University of Wisconsin, Madison
Overall Status: Completed

Phase

N/A

Condition

Stroke

Thrombosis

Blood Clots

Treatment

N/A

Clinical Study ID

NCT03232151
2015-0482
SMPH\RADIOLOGY\RADIOLOGY
1U01EB021183-01
Protocol Version 3/27/2020
A539300
  • Ages 18-99
  • All Genders

Study Summary

The overarching objective of our proposal is to develop a One-Stop-Shop imaging using the available C-arm Cone-Beam Computed Tomography (CBCT) data acquisition systems currently widely available worldwide in interventional angiography suites to enable acute ischemic stroke patients to be imaged, triaged, treated, and assessed using a single modality in one room.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients with acute ischemic stroke presenting within 8 hours of onset
  2. Patients that present with a large artery occlusion
  3. Adults 18 years of age or older.
  4. Women of childbearing potential must not be pregnant.
  5. National Institutes of Health Stroke Scale (NIHSS) of >5
  6. No severe co-morbidities

Exclusion

Exclusion Criteria:

  1. Women that are pregnant
  2. History of severe renal disease (e.g. stage 4-5)
  3. History of renal transplant

Study Design

Total Participants: 60
Study Start date:
July 01, 2017
Estimated Completion Date:
March 26, 2020

Study Description

This is an evaluation to determine the efficacy of the use of C-arm CBCT with SMART RECON novel software for the rapid assessment of time-resolved CTA and CT perfusion in the setting of ischemic cerebrovascular events. As a leading center for the treatment of cerebrovascular disease in the Midwest as well as being one of the first Comprehensive Stroke Centers in the United States we have a large potential patient group to assess.

The pilot plan is to compare conventional CT/CTA/CTP acquired during the clinical work up with C-arm CBCT/CTA/CTP acquired in the angiography suite at initiation of therapy. The C-arm CBCT acquisition provides whole brain coverage (compared to only 8 cm brain coverage with conventional CT) with less radiation and higher resolution; the CT perfusion maps obtained using C-arm CBCT and new reconstruction algorithms provides better perfusion maps.

Connect with a study center

  • University of Wisconsin, Madison

    Madison, Wisconsin 53705
    United States

    Site Not Available

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