Longitudinal Performance of Epi proColon

Inclusion Criteria:

• Average-risk subjects (no family history of colorectal cancer (CRC), no personalhistory of polyps or CRC).
• Subjects who have a history of non-compliance for CRC screening.
• After proper counseling by a health care provider, subjects who declined colonoscopyand FIT testing.
• Subjects who are 50 years of age or greater, but less than 75 years old.
• Subjects who are able to understand and sign written informed consent (IC).

Exclusion Criteria:

• Subjects defined as having elevated risk for developing CRC based on previous historyof colorectal polyps, CRC or related cancers, inflammatory bowel disease (IBD).
• Subjects with a family history of CRC, particularly with two or more first degreerelatives with CRC, or one or more first degree relative(s) less than 50 years of agewith CRC.
• Subjects who have been diagnosed with a relevant familial (hereditary) cancersyndrome, such as familial adenomatous polyposis (FAP) or non-polyposis colorectalcancer (HNPCC or Lynch Syndrome), Peutz-Jeghers Syndrome, MYH-Associated Polyposis (MAP), Gardner's syndrome, Turcot's (or Crail's) syndrome, Cowden's syndrome, JuvenilePolyposis, Cronkhite-Canada syndrome, Neurofibromatosis, or Familial HyperplasticPolyposis, or in patients with anorectal bleeding, hematochezia, or with known irondeficiency anemia.
• Subjects who are up to date for CRC screening (FOBT within preceding 12 months,flexible sigmoidoscopy or double contrast barium enema within 5 years, or colonoscopywithin 10 years).
• Subjects with comorbid illness precluding endoscopic evaluation (coronary arterydisease with myocardial infarction within 6 months, unstable angina or congestiveheart failure, chronic obstructive pulmonary disease requiring home oxygen, otherdiseases that limit life expectancy to less than 10 years).
• Subjects with chronic gastritis, or who have cancer other than colorectal, or pregnantwomen.