A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT)

Inclusion Criteria:

1. Males and females at ages 20-65 years

2. Previously diagnosed (e.g. more than 12 months ago) with primary adrenalinsufficiency due to autoimmune adrenalitis, i.e. Addison´s disease

3. A stable daily glucocorticoid replacement dose for at least 3 months prior to studyentry

4. An oral glucocorticoid replacement dose of 15-30 mg Hydrocortisone total daily dose

5. If needed, a stable fludrocortisone replacement dose for at least 3 months prior tostudy entry

6. Body mass index (BMI) of 20-35 kg/m2

7. Ability to comply to the protocol procedures and having signed informed consent toparticipate in the study

Exclusion Criteria:

1. Clinical or laboratory signs of significant cerebral, cardiovascular, respiratory,hepaticobiliary/ pancreatic disease which in the investigators judgement mayinterfere with the study assessment of completion of the study

2. Clinically significant renal dysfunction with a serum creatinine above 150 mmol/L

3. Pregnant or lactating women

4. Diabetes Mellitus

5. Systemic infections

6. Regular dehydroepiandrosterone (DHEA) medication for the past 4 weeks

7. Any medication with agents which in the investigators judgement might interfere withthe study drugs kinetics, including therapies affecting gastro intestinal emptyingor motility

8. Alcohol/drug abuse or any other condition associated with poor patient compliance,including expected non-cooperation, as judged by the investigator

9. Hypersensitivity to the active substance or any excipients used in the study drug ofchoice

10. Any additional underlying disease that may need regular or periodic pharmacologicaltreatment with glucocorticoids during the trail, such as asthma, skin- or eyeconditions treated with inhaled or topical glucocorticoids

11. Any additional underlying condition that needs treatment with intramuscular orintra-articular steroid injections during the trial