Study of TCM Syndrome of Hepatocellular Carcinoma and Colorectal Cancer Based on System Science

Phase

Condition

Digestive System Neoplasms

Neoplasms

Treatment

N/A

Clinical Study ID

NCT03189992

ShanghaiUTCM

Ages 18-85
All Genders

Study Summary

Traditional Chinese medicine (TCM) syndrome is a core foundation of disease knowledge, clinical diagnosis and treatment and curative effect evaluation in TCM. "Same TCM Syndrome for Different Diseases" and "Same Treatment for Different Diseases" is one of the characteristics of TCM syndrome differentiation and treatment.

This study is the "TCM disease syndrome combination" research baced on principles and methods of system biology, which is through acquisition of primary hepatocellular carcinoma (HCC) and colorectal cancer patients with TCM syndrome information, detection of clinical indicators and genomic, proteomic, and metabolites changes, analyzing the correlation between TCM syndromes and biological information, and revealing its biological material characteristics and the molecular mechanisms of "Same TCM Syndrome for Different Diseases";Developing and implementing the program of TCM syndrome differentiation and treatment for HCC and colorectal cancer to evaluate the efficacy of TCM syndrome based-treatment of HCC and colorectal cancer with TCM syndrom scores, clinical and systems biological indicators, quality of life and survival rate, and to revealing the mechanism of the "Same Treatment for Different Diseases".

Eligibility Criteria

Inclusion

Inclusion Criteria:

Clinical diagnosis of primary liver cancer (HCC) and colorectal cancer after surgery.
Liver cancer and colorectal cancer liver and kidney yin deficiency and spleen qideficiency syndrome diagnosis standard : Yin deficiency of liver and kidney and spleenqi deficiency syndrome see hypochondriac pain, waist and knee Limp, fever, nightsweats, dry mouth and throat, fatigue, anorexia, abdominal distension after eatingmore, red or pale tongue, less moss or Light peel, pulse fine.

Exclusion

Exclusion Criteria:

(1) there is a serious heart, kidney, and other diseases of the hematopoietic system effectof drug evaluation factors; (2)Mental disorders (3)Digestive tract obstruction; (4) poorcompliance.

Study Design

January 01, 2014

December 31, 2018

Study Description

In this study, the investigators adopted the transcriptome analysis, proteome analysis and metabolic diversity analysis of the patients with different syndromes of liver cancer and colorectal cancer, and integrate omics information, combining macro and micro methods to screen biomarkers of syndromes

Connect with a study center

Shang Hai TCM University
Shanghai,
China
Active - Recruiting

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