Glioma Microenvironment an Exploratory Study

Last updated: April 17, 2024
Sponsor: Hospital Sirio-Libanes
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Brain Cancer

Brain Tumor

Cancer/tumors

Treatment

Tumor resection

Clinical Study ID

NCT03189420
CAAE 58310716.6.0000.5461
  • Ages 18-65
  • All Genders

Study Summary

Diffuse glioms are primary brain tumors characterized by infiltrative growth and high heterogeneity, which render the disease mostly incurable. Advances in genetic analysis revealed that molecular and epigenetic alterations predict patients´s overall survival and clinical outcome. However, glioma tumorigenicity is not exclusively caused by its genetic alterations. The crosstalk between tumor cells and the surrounding microenvironment plays a crucial role in modulating glioma growth and aggressiveness. In this sense, to understand the tumor microenvironment would elucidate potential treatment alternatives. The focus will be to evaluate myeloid cells and cytokines levels.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 - 65 years old with brain tumor
  • Patients that will be submitted to brain tumor ressection

Exclusion

Exclusion Criteria:

  • Chronic neurodegenerative and inflamatory diseases

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Tumor resection
Phase:
Study Start date:
October 01, 2016
Estimated Completion Date:
December 31, 2026

Study Description

The proposal is to study gene expression and early epigenetic changes in myeloid cells from brain tumors and co-culture experiments. Tough RNA-seq, ATAC-seg and subsequent analysis to monitor the differential gene expression through different time points followed by stimuli. The study will compare the obtained results with sequencing data from microglia of full-fledged human tumor samples (glioblastoma and low grade gliomas). Additionally it will evaluated the immunologic characteristic of the tumor through cytokines levels analysis (TNF-α, IL-4, IL-6, IL-8, IL-10, IL-13, IFN-γ, TGF-β e IL-1ra).

Connect with a study center

  • Hospital Sirio Libanes

    São Paulo, Sao 01308060
    Brazil

    Site Not Available

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