ATTUNE® Revision- Complex Primary in Total Knee Arthroplasty Population

Inclusion Criteria:

1. Subject is male or female and between the ages of 22 and 80 years at the time ofconsent, inclusive.

2. The decision to have knee replacement with the study device is regardless of theresearch.

3. The devices are to be used according to the approved indications.

4. Subject that is willing to give voluntary, written informed consent to participatein this clinical investigation and authorize the transfer of his/her information tothe Sponsor

5. Subject is currently not bedridden.

6. Subject, in the opinion of the Investigator, is able to understand this clinicalinvestigation and is willing and able to perform all study procedures and follow-upvisits and co-operate with investigational procedures.

7. Subject is able to read, and comprehend the Informed Consent Document as well ascomplete the required PROMs in either English or one of the available translations.

8. Subject has not been diagnosed with an inflammatory arthritis (including gout,rheumatoid, psoriatic etc.)

Exclusion Criteria:

1. The Subject is a woman who is pregnant or lactating.

2. Contralateral knee has already been enrolled in this study. If the Investigatorplans to treat a potential study subject with either simultaneous (two (2) knees inone (1) surgical setting) or staged bilateral TKA, then this subject may beenrolled; however, only the first knee may be enrolled into this study.

3. Subject had a contralateral amputation.

4. Previous partial knee replacement (unicompartmental, bicompartmental orpatellofemoral joint replacement) or primary TKA in affected knee.

5. Subject is currently diagnosed with radicular pain from the spine that radiates intothe limb to receive TKA.

6. Subject has participated in a clinical investigation with an investigational product (drug or device) in the last three (3) months.

7. Subject is currently involved in any personal injury litigation, medical-legal orworker's compensation claims.

8. Subject, in the opinion of the Investigator, is a drug or alcohol abuser (in thelast 5 years) or has a psychological disorder that could affect his/her ability tocomplete patient reported questionnaires or be compliant with follow-uprequirements.

9. Subject was diagnosed and is taking prescription medications to treat a musculardisorder that limits mobility due to severe stiffness and pain such as fibromyalgiaor polymyalgia.

10. Subject has a significant neurological or musculoskeletal disorder(s) or diseasethat may adversely affect gait or weight bearing activities (e.g., musculardystrophy, multiple sclerosis, Charcot disease).

11. Subject has a medical condition with less than five (5) years life expectancy asdetermined by the Investigator.

12. Subject has been diagnosed with an inflammatory arthritis (including uncontrolledgout, rheumatoid, psoriatic etc.).