A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis

Inclusion Criteria:

• 1.18-75 years, males or females;

• 2.patients met the acute exacerbation of chronic bronchitis diagnosis;

• 3.Patients with bronchitis were acute attacked 2-6 days,who had a history of chronicbronchitis more than 2 years.

• 4. Patients compliance is good, written informed consent was obtained from allparticipants before the study.

Exclusion Criteria:

• 1.Patients had a history of andrographolide sulfonate or andrographolide allergy.

• 2.Pregnancy, lactation, and absence of contraception in women of fertile age.

• 3.Judging by the researchers, Past or present illness of patients may affect toparticipate in the trial or affect the outcome of the study, includingcardio-pulmonary diseases, malignant diseases, autoimmune diseases, hepatorenaldisease, blood diseases, nervous system diseases, immune system diseases and endocrinediseases

• 4.After checking, Patients with pulmonary tuberculosis, bronchial asthma, bronchialpneumonia, bronchiectasis, pneumoconiosis, silicosis, lung cancer, pulmonaryinfiltration or other allergic respiratory diseases and other chronic lung diseases

• 5.Patients using systemic steroids or other immunosuppressive therapy

• 6.Patients with severe cardiopulmonary dysfunction, abnormal liver and kidneyfunction, blood system diseases

• 7.Patients are alcohol (daily drink alcoholic wine is more than 40g) or drug abuse ordrug addicts in the past year.

• 8.Patients were participated in any study of drug trials in the last 30 days.

• 9.According to the researchers' judgment, anyone who are not suitable for the study.