Pilot Study for the Use of Photodynamic Therapy in the Treatment of Seborrheic Dermatitis

Last updated: August 4, 2021
Sponsor: University of California, Davis
Overall Status: Completed

Phase

1

Condition

Scalp Disorders

Eczema (Atopic Dermatitis - Pediatric)

Allergy

Treatment

N/A

Clinical Study ID

NCT03114111
408732
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is:

  1. To determine the efficacy of photodynamic therapy (PDT) in the treatment of seborrheic dermatitis.

  2. To determine how PDT alters the skin microbiome in subjects with seborrheic dermatitis before and after treatment.

  3. To determine how PDT alters sebum secretion rates in subjects with seborrheic dermatitis before and after treatment.

The researchers hypothesize that PDT will be efficacious in the treatment of seborrheic dermatitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy subjects 18 years or older with seborrheic dermatitis of the face will beincluded.

Exclusion

Exclusion Criteria:

  • Subjects who are taking systemic corticosteroids (at doses of prednisone greater thanor equal to 5 mg daily), antibiotics (PO, IM or IV) or using topical anti- fungals,steroids, antibiotics, permethrin, or calcineurin inhibitors within 2 weeks prior tothe study will be excluded.
  • The exclusion criteria will also include the presence of other untreated inflammatoryconditions (such as lupus, atopic dermatitis, or psoriasis) or untreated malignancieson the face (including skin cancers such as basal cell carcinoma, squamous cellcarcinoma and melanoma).
  • Any subjects with known or suspected hypersensitivity to any constituent of the studymedication or a history of photosensitivity due to conditions such as lupuserythematosus and porphyria will be excluded.
  • Subjects who have had photodynamic therapy (PDT) to the face for any reason within thepast year will be excluded as well.
  • Adults unable to consent, individuals under the age of 18, pregnant or breastfeedingwomen and prisoners will be excluded from the study.

Study Design

Total Participants: 12
Study Start date:
January 01, 2017
Estimated Completion Date:
December 04, 2019

Study Description

This pilot project investigates the use of PDT may be useful in the treatment of seborrheic dermatitis based on the following: The Malassezia spp is capable of forming biofilms, 2) PDT has been shown to be effective against Malassezia spp PDT can break up bioflims of both bacterial and fungal origin and benzoyl peroxide, a prooxidant treatment similar to PDT, has been shown to be effective in the treatment of seborrheic dermatitis.

Connect with a study center

  • University of California, Davis

    Sacramento, California
    United States

    Site Not Available

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