Study of REGN 2810 Compared to Platinum-Based Chemotherapies in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC)

Key Inclusion Criteria:

A patient must meet the following criteria to be eligible for inclusion in the study:

1. Patients with histologically or cytologically documented squamous or non squamousNSCLC with stage IIIB or stage IIIC disease who are not candidates for treatmentwith definitive concurrent chemoradiation or patients with stage IV disease whoreceived no prior systemic treatment for recurrent or metastatic NSCLC

2. Archival or newly obtained formalin-fixed tumor tissue from a metastatic/recurrentsite, which has not previously been irradiated

3. Tumor cells expressing PD L1 above a specific percentage of tumor cells by IHCperformed by the central laboratory

4. At least 1 radiographically measureable lesion per RECIST 1.1

5. ECOG performance status of ≤1

6. Anticipated life expectancy of at least 3 months

7. Adequate organ and bone marrow function

Key Exclusion Criteria:

A patient who meets any of the following criteria will be excluded from the study:

1. Patients that have never smoked, defined as smoking <100 cigarettes in a lifetime

2. Active or untreated brain metastases or spinal cord compression

3. Patients with tumors tested positive for EGFR gene mutations, ALK genetranslocations, or ROS1 fusions

4. Encephalitis, meningitis, or uncontrolled seizures in the year prior torandomization

5. History of interstitial lung disease (eg, idiopathic pulmonary fibrosis, organizingpneumonia) or active, noninfectious pneumonitis that required immune-suppressivedoses of glucocorticoids to assist with management. A history of radiationpneumonitis in the radiation field is permitted as long as pneumonitis resolved ≥6months prior to randomization

6. Patients with active, known, or suspected autoimmune disease that has requiredsystemic therapy in the past 2 years

7. Patients with a condition requiring corticosteroid therapy (>10 mg prednisone/day orequivalent) within 14 days of randomization

8. Another malignancy that is progressing or requires treatment

9. Uncontrolled infection with hepatitis B or hepatitis C or human immunodeficiencyvirus (HIV) or diagnosis of immunodeficiency

10. Active infection requiring systemic therapy within 14 days prior to randomization

11. Prior therapy with anti-PD 1 or anti-PD L1

12. Treatment-related immune-mediated AEs from immune-modulatory agents

13. Receipt of an investigational drug or device within 30 days

14. Receipt of a live vaccine within 30 days of planned start of study medication

15. Major surgery or significant traumatic injury within 4 weeks prior to first dose

16. Documented allergic or acute hypersensitivity reaction attributed to antibodytreatments

17. Known psychiatric or substance abuse disorder that would interfere withparticipation with the requirements of the study, including current use of anyillicit drugs

18. Pregnant or breastfeeding women

19. Women of childbearing potential or men who are unwilling to practice highlyeffective contraception prior to the initial dose/start of the first treatment,during the study, and for at least 6 months after the last dose

Note: Other protocol defined Inclusion/Exclusion criteria apply.