Study of Ixekizumab (LY2439821) in Children 6 to Less Than 18 Years With Moderate-to-Severe Plaque Psoriasis

Inclusion Criteria:

• Have a diagnosis of moderate-to-severe plaque-type psoriasis for at least 6 monthsprior to baseline as determined by the investigator.
• Have Psoriasis Area and Severity Index (PASI) score ≥12 and a Static Physician GlobalAssessment (sPGA) ≥3 and body surface area involvement ≥10% at screening and baseline.
• Are candidates for phototherapy or systemic treatment or considered by theinvestigator as not adequately controlled by topical therapies.
• Male subjects agree to use a reliable method of birth control during the study.
• Female subjects: Participants of childbearing age or childbearing potential who aresexually active who test negative for pregnancy must be counselled and agree to useeither 1 highly effective method of contraception or 2 acceptable methods ofcontraception combined for the duration of the study and for at least 12 weeksfollowing the last dose of study drug, or remain abstinent during the study and for atleast 12 weeks following the last dose of study drug.
• Both the child or adolescent and a parent or legal guardian are able to understand andfully participate in the activities of the clinical study and sign their assent andconsent, respectively.
• All immunizations are up-to-date in agreement with current immunization guidelines asnoted by country specific paediatric authorities (e.g., the American Academy ofPaediatrics). Note, subjects who are not up to date or have never been immunized arenot to be enrolled in the trial.

Exclusion Criteria:

• Have pustular, erythrodermic, and/or guttate forms of psoriasis.
• Have drug-induced psoriasis.
• Have clinical and/or laboratory evidence of untreated latent or active tuberculosis (TB).
• Participants with a documented history of immune deficiency syndrome.
• Have any other active or recent infection, including chronic or localized infections,within 4 weeks of baseline.
• Subjects with a known history of malignancy, lymphoproliferative disease, includinglymphoma, or signs and symptoms suggestive of possible lymphoproliferative disease,such as lymphadenopathy and/or splenomegaly unless ruled out by biopsy.
• Have used any therapeutic agent targeted at reducing interleukin-17.
• Have received other therapies within the specified time frames prior to screening (seebelow):
• adalimumab and infliximab 60 days, abatacept 90 days, anakinra 7 days, or anyother biologic disease-modifying antirheumatic drug 5 half-lives.
• systemic therapy for psoriasis and psoriatic arthritis (PsA) (other than above,eg, methotrexate, cyclosporine), phototherapy (eg, photochemotherapy [psoralenplus ultraviolet A]) in the previous 4 weeks.