Phase
Condition
Miscarriage
Treatment
N/AClinical Study ID
Ages 16-50 Female
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Twin pregnancy ( dichorionic or monochorionic diamniotic)
Both fetuses alive
Asymptomatic short cervix according to gestational age ( measurement less or equal 30mm between 16 weeks + 0 day and 22 weeks + 0 day, less or equal 25 mm between 22 weeks
- 1 day and 24 weeks + 0 day and less or equal 20 mm between 24 weeks + 1 day and 27weeks + 6 days)
Gestational age between 16 to 27weeks and 6 days
Intact membranes
Informed consent
Exclusion
Exclusion Criteria:
Monoamniotic twins
Twin Twin transfusion syndrome
Rupture membranes
Major malformation or chromosomal abnormality at least one fetus
Women with Cervical cerclage in the current pregnancy
Ballooning of membranes outside the cervix into the vagina
Placenta previa
Treatment with progesterone before randomization
Allergy of the excipientes of the micronized progesterone
Labor
Severe hepatic disfunction, porphyria, otosclerosis, severe depression
Use of drugs that interfere the effects of progesterone
Study Design
Study Description
Connect with a study center
Hospital das Clinicas da FMUSP
Sao Paulo,
BrazilActive - Recruiting
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