The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's Disease

Inclusion Criteria:

1. Age 18-65 years old, male or female;

2. refractory CD fistula, there are 1-2 and 1-3 in the mouth fistula;

3. Diagnostic CD at least three months;

4. CDAI <250;

5. were receiving drug treatment (5-ASA and hormones> 4 weeks, immunosuppressants andbiological agents> 8 weeks);

6. signed informed consent.

Exclusion Criteria:

1. with intestinal obstruction, stenosis, or perianal abscess;

2. pregnant or lactating women;

3. infection needs antibiotics persons;

4. rectovaginal fistula;

5. complex anal fistula more than two inside the mouth;

6. stenosis or perforation CD;

7. perianal infection;

8. could not do rectal or anal stenosis local injection therapy;

9. with acute enteritis;

10. , liver and kidney dysfunction;

11. a month have used other drugs are in clinical trials;

12. no conditions or unwilling to carry out MRI inspected;

13. who are adjusting therapy;

14. HIV patients;

15. The combined active hepatitis or tuberculosis; Occurred in 16) 6 months opportunisticinfections, or severe infections occur within three months;

17. In the past five years, those who suffer from cancer; 18) there is a history oflymphoproliferative disease.