Prospective Biobanking Study in Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself, Its Microenvironment and Immune Response (SCANDARE)

Last updated: January 30, 2026
Sponsor: Institut Curie
Overall Status: Active - Recruiting

Phase

N/A

Condition

Ovarian Cancer

Uterine Disorders

Nasopharyngeal Cancer

Treatment

Tumor biopsies / Tumor surgery

Blood withdrawal

Clinical Study ID

NCT03017573
IC 2016-03
  • Ages > 18
  • All Genders

Study Summary

SCANDARE is a prospective biobanking study on tumor (+/- nodes), plasma and blood samples at different time points in ovarian, triple negative breast, Head and Neck Cancer, advanced stage treatment-naïve cervical or vulva cancer and sarcoma (breast angiosarcoma and uterine sarcoma) cancers. This study will allowed to identify new molecular and/or immunological biomarkers associated with clinical and biological features of the tumors. All patients will receive standard treatment according to the stage of the diseases and usual procédures.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Tumor types :

  2. Newly diagnosed treatment-naïve ovarian cancer patients eligible for surgery orneoadjuvant chemotherapy

  3. Newly diagnosed treatment-naïve triple-negative breast cancer patients eligiblefor surgery or neoadjuvant chemotherapy

  4. Newly diagnosed treatment-naïve head and neck cancer patients eligible forsurgery

  5. Newly diagnosed treatment-naïve vulva cancer (all types) or cervical cancerpatients with (1) stage Ia - IIa1 with nodal metastasis, postoperative positivemargin or parametrial-vaginal involvement, and (2) stage ≥IIa2).

  6. Newly diagnosed treatment-naïve sarcoma cancer patients (1) breast angiosarcomaor (2) uterine sarcoma eligible for surgery or systemic treatment

  7. Male or female patients ≥ 18 years of age

  8. Signed informed consent

Exclusion

Exclusion Criteria:

  1. Male or female patients ≤18 years old

  2. Patients with any psychological, familial, sociological or geographical conditionpotentially hampering compliance with the study protocol and follow-up schedule

  3. Individually deprived of liberty or placed under the authority of a tutor

  4. Patients not affiliated to the Social Security System

Study Design

Total Participants: 1050
Treatment Group(s): 2
Primary Treatment: Tumor biopsies / Tumor surgery
Phase:
Study Start date:
January 06, 2017
Estimated Completion Date:
January 06, 2032

Study Description

Patients will have blood and +/- tumor samples at the following times :

  1. if eligible for surgery :

    • at surgery (blood + tumor and nodes)

    • after surgery (blood)

    • 6 months after surgery if non recurrence (Blood)

    • before cycle 1 of adjuvant chemotherapy or before radiotherapy (blood + tumor biopsie and nodes if possible)

    • before cycle 2 of adjuvant chemotherapy or after radiotherapy (blood)

    • at progression (blood + tumor biopsie and nodes if possible)

  2. if eligible for neoadjuvant chemotherapy :

    • before neoadjuvant therapy (blood + tumor biopsie and nodes)

    • during neoadjuvant therapy (post cycle 1) (blood)

    • at the time of surgery (blood + tumor and nodes)

    • 6 months after surgery if non recurrence (Blood)

    • before cycle 1 of adjuvant chemotherapy or before radiotherapy (blood + tumor biopsie and nodes)

    • before cycle 2 of adjuvant chemotherapy or after radiotherapy (blood)

    • at progression (blood + tumor biopsie and nodes)

Connect with a study center

  • Institut Bergonie

    Bordeaux, 33076
    France

    Site Not Available

  • Institut Bergonie

    Bordeaux 3031582, 33076
    France

    Active - Recruiting

  • Centre Oscar Lambret

    Lille, 59000
    France

    Site Not Available

  • Centre Oscar Lambret

    Lille 2998324, 59000
    France

    Active - Recruiting

  • Centre Leon Berard

    Lyon, 69373
    France

    Site Not Available

  • Centre Leon Berard

    Lyon 2996944, 69373
    France

    Active - Recruiting

  • Institut Curie

    Paris, 75005
    France

    Site Not Available

  • Institut Curie

    Paris 2988507, 75005
    France

    Active - Recruiting

  • Institut Curie Hopital Rene Huguenin

    Saint-Cloud 2981041, 92210
    France

    Active - Recruiting

  • Institut Curie Hopital Rene Huguenin

    Saint-cloud, 92210
    France

    Site Not Available

  • Institut de Cancérologie de Lorraine - Nancy

    Vandœuvre-lès-Nancy 2970797,
    France

    Site Not Available

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