A Registry Study on Genetics and Biomarkers of Thoracic Aortic Aneurysm/Dissection

Case Inclusion Criteria:

1. Subject who was diagnosed as thoracic aortic aneurysm/dissection by CT angiography,interventional angiography or vascular ultrasound;

2. Age is less than 80 years old;

3. male and non pregnancy female;

4. Subject understands study requirements aand agrees to sign an informed consent formprior to any study procedures.

Case Exclusion Criteria: Subject has one of the following:

1. Pseudoaneurysm;

2. Previous infection or trauma in the damaged part of aorta;

3. Pregnancy female;

4. Participate in other clinical trials in the last 1 months. Control Inclusion Criteria:

5. Age and gender are matched with cases;

6. No aortic disease was detected by outpatient ultrasound;

7. No family history of cardiovascular disease;

8. Normal biochemical indicators; Criteria for culling, shedding and suspension testing:

9. Culling: Unqualified cases and controls. Data of culled subjects can not be used forstatistical analysis;

10. Shedding: Subject that self withdrawal, loss to follow-up, or quitted by doctors;Reasons for shedding should be indicated for each shed subject.

11. Suspension: a) The researchers found significant safety problems or wrong studydesign; b) Researchers cannot continue clinical research due to funding or managementreasons; c) Director ends the study. When suspension happens, all the CRF table shouldbe reserved for future reference.