Exercise Effect on Chemotherapy-Induced Neuropathic Pain

Inclusion Criteria:

• Diagnosis with cancer, stage I-IV

• History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or incombination with other agents

• Completion of chemotherapy > 6 months < 1 year

• Ability to walk on a treadmill

• Medical clearance from oncologist or primary care provider

• Presence of CIPN per National Cancer Institute Common Toxicity Criteria grade 1-3 (0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interferingwith activities of daily living (ADLs), 3-severe symptoms interfering with ADL, 4-disabling, and 5 is death)

• Score on Neuropathic Pain Scale >1

• Age 21-70

Exclusion Criteria:

• Denial of CIPN

• Other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related, autoimmune diseases, diabetes)

• Coronary artery disease

• History of >1 chemotherapy regimen

• Musculoskeletal conditions which preclude participation in an exercise trainingprogram

• Pregnancy

• Regular exerciser, defined as >90 minutes per week of aerobic exercise and anyresistive training