Trial in Adult Participants With Spinocerebellar Ataxia (SCA)

Key Inclusion Criteria:

• Participants with a known or suspected diagnosis of the following specifichereditary ataxias: SCA1, SCA2, SCA3, SCA6, SCA7, SCA8 and SCA10

• Ability to ambulate 8 meters without assistance (canes and other devices allowed)

• Screening total Scale for the Assessment and Rating of Ataxia (SARA) score ≥8

• Score of ≥ 2 on the gait subsection of the SARA

• Determined by the investigator to be medically stable at baseline/randomization andmust be physically able and expected to complete the trial as designed

Key Exclusion Criteria:

• Any medical condition other than one of the hereditary ataxias specified in theinclusion criteria that could predominantly explain or contribute significantly tothe participants symptoms of ataxia

• Mini Mental State Exam (MMSE) score < 24

• SARA total score of > 30 points at screening

• Clinical history of stroke

• Active liver disease or a history of hepatic intolerance to medications that in theinvestigator's judgment, is medically significant