A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study

Inclusion Criteria:

• Subject must currently be receiving enzalutamide for prostate cancer in a studysponsored by Astellas or Medivation and, based on the investigator's assessment,benefit from continued treatment. Subjects participating in investigator-initiatedtrials are not eligible.

• Subject is able to continue on the treatment regimen that the subject was receivingin the prior study. If in the investigator's assessment, a change is needed to thesubject's regimen (e.g., dose change in Androgen deprivation therapy (ADT) ordropping of a combination therapy) approval from a medical monitor is required priorto enrollment.

• Subject is able to swallow enzalutamide capsules and comply with study requirements.

• Subject and female partner who is of childbearing potential must continue to use 2forms of birth control, of which 1 must be highly effective and 1 must be a barriermethod throughout the study and for 3 months after final enzalutamideadministration.

• Subject agrees to avoid sperm donation during the study and for at least 3 monthsafter final enzalutamide administration.

• Subject agrees not to participate in another interventional study while ontreatment.

Canada Specific:

• Institutional Review Board (IRB)/Independent Ethics Committee (IEC) approved writtenInformed Consent and privacy language as per national regulations (e.g., HealthInsurance Portability and Accountability Act authorization for the United Statessites) must be obtained from the subject prior to any study-related procedures.

• Subject must currently be receiving enzalutamide for breast cancer in a studysponsored by Astellas or Medivation/Pfizer and based on the investigator'sassessment, benefit from continued treatment. Subjects participating ininvestigator-initiated trials are not eligible.

• Subject is able to continue on the treatment regimen that they were receiving in theprior study. If in the investigator's assessment, a change is needed to thesubject's regimen (e.g., dropping of a combination therapy) approval from a medicalmonitor is required prior to enrollment.

• Subject is able to swallow enzalutamide capsules and comply with study requirements.

• Subject is either:

• Of nonchildbearing potential:

• postmenopausal (defined as no spontaneous menses for at least 12 months prior to Day 1 with follicle stimulating hormone (FSH) > 40 IU/L at Day 1 for women < 55 years ofage),

• documented surgically sterile or status post hysterectomy (at least 1 month prior toDay 1),

• Or, if of childbearing potential,

• must have a negative urine pregnancy test at Day 1 before the first dose of studydrug is administered,

• must use 2 acceptable methods of birth control starting at Day 1 and through 6months after the final study drug administration,

• must not donate ova starting at first administration of study intervention andthroughout 6 months after final study intervention administration.

The 2 acceptable methods of birth control are as follows or per local guidelines where these require additional description of contraceptive methods:

• A barrier method (e.g., condom by a male partner) is required; AND

• One of the following is required:

• Placement of an intrauterine device (IUD) or intrauterine system (IUS);

• Additional barrier method including occlusive cap (diaphragm or cervical/vault caps)with spermicidal foam/gel/film/cream/suppository;

• Vasectomy or other surgical castration at least 6 months before Day 1.

• The subject must not be breastfeeding at Day 1 or during the study period, and for 6months after the final study drug administration.

• Subject agrees not to participate in another interventional study while ontreatment.

Exclusion Criteria:

• Subject met any of the discontinuation criteria or whose cancer progressed on thecurrent enzalutamide clinical study in which subject is enrolling from.

• Subject requires treatment with or plans to use either of the following:

• New systemic therapy for subjects cancer (palliative radiation therapy isallowed). The treatment with agents administered during previous studies whichwas stopped and then restarted during this study does not represent newtreatment.

• Investigational therapy other than enzalutamide.

• Subject is currently participating in an investigator-initiated interventional trialand receiving enzalutamide.

• Subject has any concurrent disease, infection, or comorbid condition that interfereswith the ability of the subject to participate in the study, which places thesubject at undue risk or complicates the interpretation of data.

Canada Specific:

Subject will be excluded from participation if any of the following apply:

• Subject met any of the discontinuation criteria or whose cancer progressed on thecurrent enzalutamide clinical study in which they are enrolling from.

• Subject requires treatment with or plans to use any of the following:

• New systemic therapy for their cancer (palliative radiation therapy is allowed). Thetreatment with agents administered during previous studies which was stopped andthen restarted during this study does not represent new treatment.

• Investigational therapy other than enzalutamide.

• Subject is currently participating in an investigator-initiated interventional trialand receiving enzalutamide.

• Subject has any concurrent disease, infection, or comorbid condition that interfereswith the ability of the subject to participate in the study, which places thesubject at undue risk or complicates the interpretation of data in the opinion ofthe investigator.