Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility

Last updated: September 8, 2020
Sponsor: University Hospital, Lille
Overall Status: Active - Recruiting

Phase

N/A

Condition

Infertility

Endometriosis

Treatment

N/A

Clinical Study ID

NCT02948972
2015_02
2015 A01536-43
  • Ages 18-38
  • Female

Study Summary

The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility. Patients will be randomized in two parallel-groups; one group underwent complete surgery of colorectal DIE prior to ART and the other group underwent ART alone (ratio 1:1)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Primary and secondary infertility

  • Indication for IVF

  • Persistent pain related to endometriosis with analgesic medical treatment failure

  • Persistent pain including at least one of the following digestive symptoms related toendometriosis: Dyschesia / Sub-occlusive syndrome / Rectal bleeding / Painfuldefecation

  • Colorectal deep infiltrating endometriosis : Whatever lesion size / With at leastrectal serosal involvement / Confirmed by MRI and 1 different investigation: vaginalultrasound echography or coloscopic CT scan or rectal endoscope ultrasound

  • Eligible for DIE surgery

Exclusion

Exclusion Criteria:

  • Contraindication to pregnancy or to IVF

  • Viral risk

  • Previous IVF cycle(s)

  • Previous colorectal surgery

  • Need of myomectomy during surgery

  • The use of oocytes donor

Study Design

Total Participants: 120
Study Start date:
November 17, 2016
Estimated Completion Date:
May 31, 2025

Connect with a study center

  • CHU

    Clermont-Ferrand,
    France

    Active - Recruiting

  • Hôpital Jeanne de Flandres, CHRU

    Lille,
    France

    Active - Recruiting

  • AP-HP, Hôpital Tenon

    Paris,
    France

    Active - Recruiting

  • CHU

    Poissy,
    France

    Active - Recruiting

  • CHU

    Rouen,
    France

    Active - Recruiting

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