Effects of Lactobacillus Reuteri Plus Vitamin D3 in Children With Atopic Dermatitis

Last updated: March 21, 2023
Sponsor: Noos S.r.l.
Overall Status: Completed

Phase

N/A

Condition

Rash

Atopic Dermatitis

Allergy

Treatment

N/A

Clinical Study ID

NCT02945683
ATOPIA_D3
  • Ages 1-4
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to evaluate in a randomized, double-blinded, controlled trial, whether a new food supplement containing Lactobacillus reuteri DSM 17938 and vitamin D3 (Reuterin® D3) may improve the SCORAD in pediatric patients with mild to moderate atopic dermatitis

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosis of atopic dermatitis of mild to moderate grade (SCORAD 25-50)
  • signature of the informed consent from both parents or a legal representative

Exclusion

Exclusion Criteria:

  • presence of autoimmune diseases, immunodeficiency, inflammatory bowel diseases, cysticfibrosis, metabolic diseases
  • use of immunosuppressive drugs and/or systemic corticosteroids in the previous 2months
  • use of antibiotics in the last 4 weeks
  • use of probiotics and/or prebiotics in the last 2 weeks
  • use of vitamin D in the last 4 weeks
  • participation in other clinical trials

Study Design

Total Participants: 88
Study Start date:
February 01, 2015
Estimated Completion Date:
February 28, 2018

Study Description

Recent evidence suggests that childhood allergy development can be linked to an imbalance of the intestinal microbiota. The probiotic bacteria, which contribute to the balance of the intestinal microflora, may play a key role in the modulation of the immune response, looking as a potential resource in the prevention or treatment of allergic disorders.

In this study the investigators will recruit pediatric patients with atopic dermatitis of mild-to-moderate degree, for which the standard treatment consists in using an emollient cream and topical steroids in case of exacerbation.

The investigators assume that participants can receive significant benefits from the addition to their standard treatment of a food supplement containing L. reuteri DSM 17938 and vitamin D3, which, thanks to their beneficial effects on intestinal microbiota and on modulation of the immune response, may compensate for the inadequate capacity of these patients to produce antimicrobial peptides in response to cutaneous aggressions, improving, therefore, the severity of the disease.

88 children of both sexes, between 1 and 4 years old, with a SCORAD of 25-50 will be selected as a part of routine outpatient visits at the Pediatric Allergy Department of the University Hospital of Verona.

The study product (active or placebo) will be administered for 3 months, with a follow-up period of further 3 months. From all participants, at time 0 and after 3 months, blood and stool samples will be collected for the analysis of vitamin D and cathelicidin levels and for the analysis of microflora respectively.

Connect with a study center

  • Policlinico G.B. Rossi

    Verona, 37134
    Italy

    Site Not Available

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