Edoxaban Treatment Versus Vitamin K Antagonist (VKA) in Patients With Atrial Fibrillation (AF) Undergoing Catheter Ablation

Inclusion Criteria:

• Male or female at least 18 years of age with documented history of paroxysmal (lasting ≤7 days), persistent (lasting >7 days but ≤12 months) or long-standing [long-lasting]persistent (>12 months) non-valvular AF. Duration of AF can be confirmed by anyelectrical tracing or a recording in the subject's medical records (e.g., medicalchart, hospital discharge summary).

• Subject is eligible and is scheduled for either radio frequency (RF) or cryoballooncatheter ablation (both first and repeated procedure included).

• Signed informed consent form (ICF).

Exclusion Criteria:

• AF considered to be of a transient or reversible nature (such as in myocarditis,post-surgery, ionic disturbances, thyrotoxicosis, pneumonia, severe anemia etc.).

• Subject post stroke, or with a systemic thromboembolic event within the past 6 monthsprior to randomization.

• Subject has a thrombus in the left atrial appendage (LAA), left atrium (LA), leftventricle (LV), or aorta, or an intracardial mass.

• Subject had a myocardial infarction (MI) within the 2 months prior to randomization orcoronary artery bypass graft (CABG) surgery within 3 months prior to therandomization.

• Subject has signs of bleeding, history of clinically-relevant bleeding according toInternational Society on Thrombosis and Hemostasis (ISTH), or conditions associatedwith high risk of bleeding

• Subjects with any contraindication for anticoagulant agents.