An Add-on Study to Evaluate the Efficacy and Safety of Xiyanping Injection in Pediatric Bronchitis Patients.

Inclusion Criteria:

• Clinical diagnosis of pediatric bronchitis with hospital treatment needed

• Males and female subjects

• Age between 1 and 3 years old

• With fever, cough, gasp and expectoration symptoms

• Have wheeze and/ or mid-fine rales on one's lungs

• White blood cell count < 12 x 109 / L, categorized priority to leukocyte

• C-reactive protein≤8mg/L or normal Super C- reactive protein

• Had experienced ≤48 h course before enrollment

• Previous Wheezing episodes≤2

• Written informed consent

Exclusion Criteria:

• Participants with severe clinical symptoms, meet any of the following：

• SaO2≤0.92;（2）Shock or disturbance of consciousness;（3） Significantly speed upbreathing , rapid pulse accompany with severe respiratory distress; or（4）Repeatedoccurrence of apnea or slow and irregular respiration;

• Acute infectious disease such as measles, pertussis and influenza

• Participants with bronchial asthma, bronchopneumonia and other respiratory diseases

• Chronic lung diseases

• Participants with complicated pyopneumothorax, airway obstruction, toxicencephalopathy, cardiac failure or respiratory failure

• Participants with complicated severe underlying myocardial, liver, kidney, digestiveand hematopoietic system diseases

• Severe malnutrition and history of immune deficiency which may seriously affect theself-limiting process of the course

• Participants with epilepsy and other disturbances of central nervous system

• Participants with congenital diseases and psychosis

• use of any other antiviral drugs within the 2 weeks before enrollment

• use of systemic hormone within the 2 weeks before enrollment

• Participants had a history of allergic constitution and drug allergy; Allergenic toXiYanPing injection and Andrographolide

• Participants participated in other clinical research in the last three months

• Any condition which would make the subject, in the opinion of the investigator ordesignee, not suitable for the study for any reason