Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine

Phase

Condition

Allergies & Asthma

Asthma

Treatment

N/A

Clinical Study ID

NCT02937207

LH20161013

Ages 18-45
All Genders
Accepts Healthy Volunteers

Study Summary

The purpose of this study is to evaluate the clinical efficacy of traditional Chinese medicine in the treatment of asthma, and to promote the application in community hospitals.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Patients had positive bronchodilator reversibility test or positive bronchialchallenge test or more than 50 parts per billion of FENO before
Number of months without control between 1 and 3 months last year
The course of asthma was more than 10 years and less than 30 years
Conform to the predetermined 4 TCM Syndrome Types
Patients who have given written informed consent

Exclusion

Exclusion Criteria:

Smoking and continuous exposure to hazardous environment
With fever, or severity of intermittent state, high degree of sustained, or withrespiratory failure, etc.
Long term inhaled corticosteroids (more than 5 years) prior to study entry
Pulmonary emphysema, chronic obstructive pulmonary disease, pulmonary emphysema,pulmonary heart disease, pneumonia, lung cancer and other lung diseases
Rheumatic immune disease, diabetes, hyperthyroidism, menopause, gastroesophagealreflux, arrhythmia and other complications of the disease
Heart, liver, kidney and other organ dysfunction
Accompanied by other diseases of long-term use of glucocorticoids, anti allergy drugs,mental or neurological drugs or traditional Chinese Medicine
Patients who are allergic to therapeutic medicine
Female patients in lactation period, pregnancy or planning to get pregnant during thetrial
Patients with mental or neurological disorders

Study Design

July 30, 2017

December 31, 2021

Study Description

Asthma is a serious global health problem and has increasing prevalence in many countries.Although asthma symptoms can be controlled by drug treatment to a large extent, there is still inadequate.Traditional Chinese medicine has a long history of treating asthma, and has a good clinical curative effect.The purpose of this study is to evaluate the clinical efficacy of traditional Chinese medicine in the treatment of asthma, and to promote the application in community hospitals. This could constitute a significant advance in asthma management.

In this study, the investigators recruited patients with asthma exacerbation and remission stage, and gave the corresponding western medicine background treatment and traditional Chinese medicine treatment program.Participants will undergo a physical examination, lung function, blood and sputum collection.

Exacerbation group belongs to cold type of asthma patients will take Ke Chuan Liu Wei Mixture, wind phlegm type of asthma patients will take Chuan Xiong Ping Chuan Mixture and Xie Wu Capsule，and hot type of asthma patients will take Dan Ma Jia Tablet for 14 days treatment, while the 3 control groups were given 3 corresponding placebo treatment for a total of 14 days.

Remission phase of Yang deficiency patients in treatment group will take Zhi Chuan Capsule and Bu Shen Na Qi Granule, and in control group received a placebo treatment for a total of 60 days.

Study visits will occur for 7 days of exacerbation group and 1 year for remission group. Questionnaires to assess asthma control will be completed during study of asthma at exacerbation stage within 44 days and on remission period within 12 months.

Connect with a study center

Fenglin Street Community Health Service Center
Shanghai, Shanghai 200030
China
Site Not Available
Fengxian District Hospital of TCM
Shanghai, Shanghai 201400
China
Site Not Available
Kangjian Street Community Health Service Center
Shanghai, Shanghai 200030
China
Site Not Available
Longhua Hospital Affiliated Shanghai University of TCM
Shanghai, Shanghai 200032
China
Active - Recruiting
Tianping Street Community Health Service Center
Shanghai, Shanghai 200030
China
Site Not Available

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