Measuring the Glycemic Index and Tracking Metabolites of New and Emerging Lentil Varieties

Phase

N/A

Condition

Diabetes Mellitus, Type 2

Diabetes And Hypertension

Diabetes Mellitus Types I And Ii

Treatment

N/A

Clinical Study ID

NCT02909803

Lentil metabolites

Ages 18-75
All Genders
Accepts Healthy Volunteers

Study Summary

It is not known whether different lentil varieties have the same efficacy in lowering blood glucose. Similarly, the carbohydrate component of lentils responsible for lowering blood glucose is not known, nor is the bioavailability of lentil metabolites and polyphenol bioactive.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Male or non-pregnant females, 18-75 years of age, inclusive
Body mass index (BMI) < 40 kg/m²
Willing to maintain habitual diet, physical activity pattern, and body weightthroughout the trial and to refrain from smoking for 12hr prior to each visit.
Normal fasting serum glucose (<7.0mmol/L capillary corresponding to whole bloodglucose <6.3mmol/L).
Understanding the study procedures and willing to provide informed consent toparticipate in the study and authorization to release relevant protected healthinformation to the study investigator.

Exclusion

Exclusion Criteria:

Failure to meet any one of the inclusion criteria
Known history of AIDS, hepatitis, diabetes or a heart condition
Subjects using medications or with any condition which might, in the opinion of Dr.Wolever, the Medical Director of GI Labs, either: 1) make participation dangerous tothe subject or to others, or 2) affect the results.
Major trauma or surgical event within 3 months of screening.
Unwillingness or inability to comply with the experimental procedures and to follow GILabs safety guidelines.
Known intolerance, sensitivity or allergy to any ingredients in the study products.

Study Design

January 01, 2013

July 31, 2016

Study Description

The overall aim of this work is to produce credible evidence for substantiating a food health claim for post prandial blood glucose lowering by lentil. Although several studies have shown that lentil consumption results in a lowering of post prandial blood glucose, it is not known whether different lentil varieties have the same efficacy. Similarly, the carbohydrate component of lentils responsible for lowering blood glucose is not known, nor is the bioavailability of lentil metabolites and polyphenol bioactive. The investigators hypothesize that the slowly digestible starch content of lentil is inversely related to in vivo glycemic response. The specific aims of this study are: (i) to identify the putative component(s) in lentil that might account for its blood glucose lowering effect, and (ii) to identify differences in blood glucose reduction among lentil varieties. These aims will be achieved in a three-step process. Firstly, in vitro studies will be pursued to determine the carbohydrate fractions of 20 new and emerging Canadian lentil varieties. Secondly, these results will be used to choose 8 lentil varieties with different slowly digestible starch content for a human Glycemic Index study. Thirdly, identification of lentil metabolites will be achieved by collecting extra capillary blood (200uL)and urine samples at fasting and 120min for measurement of polyphenols and metabolites using established HPLC and metabolomics techniques.

Connect with a study center

Glycemic Index Laboratories, Inc
Toronto, Ontario M5C 2N8
Canada
Site Not Available

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