Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy

Inclusion Criteria:

Newborn infants whose gestational age ≥37 weeks' gestation, weighing over 2500 g ;

Acute perinatal event (e.g., late or variable decelerations, cord prolapse, cordrupture, uterine rupture, maternal trauma, hemorrhage, or cardiorespiratoryarrest)

With an Apgar score ≤ 3 at one minute and ≤5 at five minutes, and/or a potentialof hydrogen of 7.0 or less or a base deficit of 16 mmol per liter or more in asample of umbilical-cord blood or any blood during the first hour after birth.

Having moderate-to-severe encephalopathy (indicated by lethargy, stupor, or coma)and either hypotonia, abnormal reflexes (including oculomotor or pupillaryabnormalities), an absent or weak suck, or clinical seizures, and/or haveabnormal background activity of at least 20 minutes' duration or seizures onamplitude integrated electroencephalography

Exclusion Criteria:

A congenital and the hereditary disease, a chromosome abnormalities, and acongenital abnormality.

During the acute phases of intracranial and (or) fundus hemorrhage. o

Intracranial infection.

Pneumothorax.

Infants who have been received hypothermia.