Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism

Inclusion Criteria Criteria A

• Boy >14yr without any sign of puberty, testis <4ml

• BA ≥12yr

• Sex hormone (LH,FSH, T) are pre-pubertal level

• No other hormones problems (other pituitary glands axis are normal except gonad axis)

• No space occupying lesion, No tumor on MRI of pituitary and hypothalamus area

• Kallmann's syndrome(KS) patients may companies with dysosmia or dysplasia of olfactorybulb or olfactory tract on MRI

• Karyotype is 46，XY

• Exclude chronic diseases, malnutrition Criteria B

• For the boy <14yr. who companies with micropenis or cryptorchid or hypospadias andthey have anosmia or dysplasia of olfactory bulb/olfactory sulcus/olfactory structs onMRI include in. Criteria C

• As the phenotype of hypogonadotropic hypogonadism are variant, some of them may havepartial puberty. So, we enrolled them when they have testis volume >4ml or thetestosterone level 〉200ng/L，companies anosmia or dysplasia of olfactory bulb /olfactory sulcus/ olfactory structs on MRI, and the puberty arrested in half a year.These patients can be diagnosed as Kallmann Syndrome.

Exclusion Criteria:

• Any ascertain reason contributes to the non puberty development (Chromosome abnormal,trauma, surgeries) or any ascertain disease such as Prader-Willi syndrome orhypergonadotropic hypogonadism

• Systemic diseases (such as chronic kidney failure, Mediterranean anemia, poorcontrolled diabetes)

• Protein-energy malnutrition

• Eating disorder (such as anorexia nervosa, binge eating)

• Any brain diseases history: tumors in brain or pituitary or after their surgeries