Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

Last updated: March 26, 2019
Sponsor: Axovant Sciences Ltd.
Overall Status: Terminated

Phase

2

Condition

Dementia

Parkinson's Disease

Sleep Disorders

Treatment

N/A

Clinical Study ID

NCT02871427
RVT-102-2003
  • Ages > 50
  • All Genders

Study Summary

This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia (LBD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects with LBD who completed a previous nelotanserin VH or RBD study

Exclusion

Exclusion Criteria:

  • Subjects with a current serious and/or unstable cardiovascular, respiratory, thyroid,gastrointestinal, renal, hematologic or other medical disorder

Study Design

Total Participants: 80
Study Start date:
October 20, 2016
Estimated Completion Date:
January 17, 2019

Study Description

This is a multi-center open-label, long-term study in LBD subjects with RBD and/or VHs. Eligible subjects who completed a previous nelotanserin VH or RBD study and choose to participate in this open-label study will receive 20, 40, 60, or 80 mg nelotanserin once daily for 24 weeks.

Connect with a study center

  • US120

    Birmingham, Alabama 35294
    United States

    Site Not Available

  • US143

    Little Rock, Arkansas 77205
    United States

    Site Not Available

  • US123

    Fountain Valley, California 92708
    United States

    Site Not Available

  • US114

    Boca Raton, Florida 33486
    United States

    Site Not Available

  • US180

    Maitland, Florida 32751
    United States

    Site Not Available

  • US154

    Ocala, Florida 34471
    United States

    Site Not Available

  • US113

    Orlando, Florida 32806
    United States

    Site Not Available

  • US152

    Ormond Beach, Florida 32174
    United States

    Site Not Available

  • US107

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • US132

    Lenexa, Kansas 66214
    United States

    Site Not Available

  • US103

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • US129

    Lincoln, Nebraska 68526
    United States

    Site Not Available

  • US101

    Chapel Hill, North Carolina 27514
    United States

    Site Not Available

  • US147

    Fargo, North Dakota 58103
    United States

    Site Not Available

  • US111

    Cincinnati, Ohio 45229
    United States

    Site Not Available

  • US104

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • US105

    Columbus, Ohio 43210
    United States

    Site Not Available

  • US173

    Lincoln, Rhode Island 02865
    United States

    Site Not Available

  • US128

    Memphis, Tennessee 38163
    United States

    Site Not Available

  • US131

    San Antonio, Texas 78229
    United States

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.