Bladder Directed vs. Pelvic Floor Therapy in IC/BPS

Inclusion Criteria:

• Female

• Age 18 to 85 years

• History of patient self-reported of IC/BPS symptoms for at least 6 months.

• Using an approved method of birth control, or surgically sterile, or of non-childbearing age with no menstrual period for the past 12 months

• Must be willing to not start any new medication known to affect bladder or musclefunction, and to ideally remain on a stable dose of all other medications throughthe secondary endpoint.

Exclusion Criteria:

• Active urethral or ureteral calculi, urethral diverticulum, history of pelvicradiation therapy, tuberculous cystitis, bladder cancer, carcinoma in situ (bladder), urethral cancer

• Hunner's lesions found on screening cystoscopy

• Prior investigational or therapeutic bladder instillations for IC/BPS symptomswithin the past 3 months

• Lactation, pregnancy, or refusal of medically approved/reliable birth control inwomen of child-bearing potential.

• Pain, frequency, and/or urgency symptoms only present during menses

• Clinically confirmed urinary tract infection at time of screening

• Participant unable to tolerate insertion of one or two vaginal examining fingers (e.g. Vulvar allodynia)

• Participant had prior course of physical therapy (PT) that included internal (vaginal and/or rectal) manual therapy with connective tissue manipulation byphysical therapist for the same symptoms within the past 3 months (prior treatmentby therapist with biofeedback, electrical stimulation, or pelvic floor exercises isnot exclusionary)

• Participant in the opinion of the investigator has a relevant neurologic disorderthat affects bladder and/or neuromuscular function

• Participant has/reports any severe, debilitating or urgent concurrent, medicalcondition

• Participant has a potentially significant pelvic pathology or abnormality onexamination or prior imaging, including prolapse beyond the hymenal ring, pelvicmass, etc., that in the investigators' judgment, could cause or contribute to theclinical symptoms, or require treatment

• Any other condition which, in the investigator's judgment, may increase risk tosubject's welfare

• Participation in an investigational trial that uses a study treatment less than 6months from the date of the screening visit

Note: For the sake of preserving scientific integrity, one or more of the eligibility criteria have been left off the list posted while the trial is ongoing. A full list of eligibility criteria will be posted upon completion of the trial.