Efficacy and Safety of GSP 301 Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (SAR)

Inclusion Criteria:

• Males and non-pregnant females who are 12 years of age and older.

• Documented clinical history of SAR (for at least 2 years preceding the Screening Visit [Visit 1]) with exacerbations (clinical evidence of active symptoms) for the relevantseasonal allergen during the Fall or mountain cedar allergy seasons (e.g., ragweed ormountain cedar pollen)

• A 12-hour rTNSS ≥8 out of a possible 12 and a congestion score ≥2 for the AMassessment at the Screening Visit (Visit 1).

Exclusion Criteria:

• Pregnant or lactating women.

• History of anaphylaxis and/or other severe local reaction(s) to skin testing.

• History of positive test for HIV, Hepatitis B or Hepatitis C infection.

• Documented evidence of acute or significant chronic sinusitis or chronic purulentpostnasal drip.

• Subjects with an active pulmonary disorder or infection.

• Subjects with posterior subcapsular cataracts or glaucoma

• Plans to travel outside the known pollen area for the investigational site for 24hours or longer during the last 7 days of the run-in period.