One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis

Inclusion Criteria:

1. Persons with confirmed early symptomatic syphilis (primary or secondary) or high-titerlatent syphilis

2. A rapid plasma reagin (RPR) test was positive, with a titer were 1:4 or higher. Inaddition, Treponema pallidum particle agglutination assay and/or fluorescenttreponemal antibody absorption test were reactive.

Exclusion Criteria:

1.Patients who were pregnancy, known allergy to penicillin, use of antibiotics activeagainst syphilis during the preceding six months for symptomatic cases or during thepreceding two years for asymptomatic cases, and concurrent illnesses requiring treatmentwith antibiotics effective against syphilis. 2. if RPR titers were found to be 1:4 or lessor the T. pallidum particle agglutination test was nonreactive, participants wereretrospectively excluded from the trial unless primary syphilis was confirmed by thefinding of T. pallidum in ulcer exudates on direct immunofluorescence