Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection

Phase

N/A

Condition

Aneurysm

Heart Disease

Cardiovascular Disease

Treatment

N/A

Clinical Study ID

NCT02852603

2016LMC-2

Ages 18-80
All Genders

Study Summary

Mortality of thoracic aortic aneurysm and dissection (TAAD) remains high because of the huge blood lost from the aorta. Questions about the potentially genetic effects on sporadic TAAD are raised by researchers to explore the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Patients with thoracic aortic aneurysm and dissection not due to trauma

Exclusion

Exclusion Criteria:

Inability of the patient, parent or guardian to give consent
Unwillingness to provide a blood specimen or participate in the study

Study Design

August 01, 2014

January 31, 2020

Study Description

Thoracic aortic dissection (TAD) is a critical clinical condition partly due to the rupture of aortic aneurysm. Mostly, surgical treatment can reduce the symptoms and extend life span of patients with thoracic aortic aneurysm and dissection (TAAD). However, mortality of TAAD remains high because of the huge blood lost from the aorta. Sporadic TAAD was considered to be a server consequence of hypertension, though most patients with hypertension won't have TAAD as their final outcomes. Previous studies have revealed the associations between genetic abnormalities and familial TAAD, and genetic tests have applied to assist the diagnosis of certain TAAD. Therefore, the potentially genetic effects on sporadic TAAD are explored by researchers to understand the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Connect with a study center

Wuhan Asia Heart Hospital
Wuhan, Hubei 430022
China
Site Not Available

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